about
Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domainCloning and characterization of a human orphan family C G-protein coupled receptor GPRC5DThe rat GPRC6A: cloning and characterizationPositive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEPThe glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterizationCrystal Structure and Pharmacological Characterization of a Novel N-Methyl-D-aspartate (NMDA) Receptor Antagonist at the GluN1 Glycine Binding Siteα4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)Biased agonism of the calcium-sensing receptorPharmacology of muscarinic acetylcholine receptor subtypes (m1-m5): high throughput assays in mammalian cellsMolecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay.Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay.Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists.The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists.Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.The use of Xenopus oocytes in drug screening.Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.Mutation-induced quisqualic acid and ibotenic acid affinity at the metabotropic glutamate receptor subtype 4: ligand selectivity results from a synergy of several amino acid residues.Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile.Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.Novel high-affinity and selective biaromatic 4-substituted gamma-hydroxybutyric acid (GHB) analogues as GHB ligands: design, synthesis, and binding studies.Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technologyKnown regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A.Selective Allosteric Antagonists for the G Protein-Coupled Receptor GPRC6A Based on the 2-Phenylindole Privileged Structure Scaffold.Molecular pharmacology of human NMDA receptorsDifferential compartmentalization and distinct functions of GABAB receptor variants.Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo.Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male miceMolecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients.Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.The emerging role of promiscuous 7TM receptors as chemosensors for food intake.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Hans Bräuner-Osborne
@ast
Hans Bräuner-Osborne
@en
Hans Bräuner-Osborne
@es
Hans Bräuner-Osborne
@nl
Hans Bräuner-Osborne
@sl
type
label
Hans Bräuner-Osborne
@ast
Hans Bräuner-Osborne
@en
Hans Bräuner-Osborne
@es
Hans Bräuner-Osborne
@nl
Hans Bräuner-Osborne
@sl
prefLabel
Hans Bräuner-Osborne
@ast
Hans Bräuner-Osborne
@en
Hans Bräuner-Osborne
@es
Hans Bräuner-Osborne
@nl
Hans Bräuner-Osborne
@sl
P1053
D-7260-2011
P106
P1153
7003521337
P21
P31
P3829
P496
0000-0001-9495-7388