A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter
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The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyThe Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATEATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingRobust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric ModulatorsThe silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunctionObligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerizationThe Concise Guide to PHARMACOLOGY 2013/14: ion channelsConserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Cystic fibrosis transmembrane conductance regulator (CFTR) potentiator VX-770 (ivacaftor) opens the defective channel gate of mutant CFTR in a phosphorylation-dependent but ATP-independent manner.A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator.The CFTR ion channel: gating, regulation, and anion permeationCFTR mutations altering CFTR fragmentation.Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channelsCFTR: folding, misfolding and correcting the ΔF508 conformational defect.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.Functional architecture of the CFTR chloride channel.Structural Changes Fundamental to Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Anion Channel Pore.Interaction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel.Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.Escherichia coli-induced epithelial hyporesponsiveness to secretagogues is associated with altered CFTR localization.Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange.
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P2860
A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporter
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 February 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A unified view of cystic fibro ...... ing cassette (ABC) transporter
@en
A unified view of cystic fibrosis transmembrane conductance regulator
@nl
type
label
A unified view of cystic fibro ...... ing cassette (ABC) transporter
@en
A unified view of cystic fibrosis transmembrane conductance regulator
@nl
prefLabel
A unified view of cystic fibro ...... ing cassette (ABC) transporter
@en
A unified view of cystic fibrosis transmembrane conductance regulator
@nl
P2860
P356
P1476
A unified view of cystic fibro ...... ing cassette (ABC) transporter
@en
P2093
Kevin L Kirk
P2860
P304
12813-12819
P356
10.1074/JBC.R111.219634
P407
P577
2011-02-04T00:00:00Z