Genetic modeling of gliomas in mice: new tools to tackle old problems.
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In vivo models of primary brain tumors: pitfalls and perspectives.Mouse models of cancer: Sleeping Beauty transposons for insertional mutagenesis screens and reverse genetic studiesWill kinase inhibitors make it as glioblastoma drugs?Contemporary murine models in preclinical astrocytoma drug developmentThe nuclear receptor TLX is required for gliomagenesis within the adult neurogenic niche.PTEN regulation of local and long-range connections in mouse auditory cortex.Immunocompetent murine models for the study of glioblastoma immunotherapyLentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H.Toward 3D biomimetic models to understand the behavior of glioblastoma multiforme cellsSurvivin transcript variant 2 drives angiogenesis and malignant progression in proneural gliomas.DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification.Akt and c-Myc induce stem-cell markers in mature primary p53⁻/⁻ astrocytes and render these cells gliomagenic in the brain of immunocompetent mice.A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.The orthotopic xenotransplant of human glioblastoma successfully recapitulates glioblastoma-microenvironment interactions in a non-immunosuppressed mouse model.CSF-1R inhibition alters macrophage polarization and blocks glioma progression.Transposon mediated integration of plasmid DNA into the subventricular zone of neonatal mice to generate novel models of glioblastoma.Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe.Epidermal growth factor receptor targeting and challenges in glioblastoma.Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide.Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas.Evolutionary etiology of high-grade astrocytomas.Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedulesGlioma: experimental models and reality.Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge.Standard of care therapy for malignant glioma and its effect on tumor and stromal cells.Genetic approaches to study glial cells in the rodent brain.Paediatric and adult malignant glioma: close relatives or distant cousins?Animal models for glioma drug discovery.The molecular landscape of diffuse glioma and prospects for biomarker development.Brain stem cells as the cell of origin in glioma.Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes.Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma.Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.Primary orthotopic glioma xenografts recapitulate infiltrative growth and isocitrate dehydrogenase I mutation.Suppression of autophagy impedes glioblastoma development and induces senescence.Integrating the glioblastoma microenvironment into engineered experimental models.Glioblastoma heterogeneity and more accurate representation in research models.Double minute amplification of mutant PDGF receptor α in a mouse glioma model.
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Genetic modeling of gliomas in mice: new tools to tackle old problems.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 08 February 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@en
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@nl
type
label
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@en
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@nl
prefLabel
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@en
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@nl
P2093
P2860
P356
P1433
P1476
Genetic modeling of gliomas in mice: new tools to tackle old problems.
@en
P2093
Al Charest
Dolores Hambardzumyan
Eric C Holland
Luis F Parada
P2860
P304
P356
10.1002/GLIA.21142
P577
2011-02-08T00:00:00Z