Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype. - Wikidata - awgldk - TriplyDB

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

http://www.wikidata.org/entity/Q37847790

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The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover RNA-binding protein nucleolin in disease The notorious R.N.A. in the spotlight - drug or target for the treatment of disease α-Thalassemia associated with hb instability: a tale of two features. the case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro AUF-1 and YB-1 independently regulate β-globin mRNA in developing erythroid cells through interactions with poly(A)-binding protein Two novel C-terminal frameshift mutations in the β-globin gene lead to rapid mRNA decay.Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health.Phenotypic Evaluation of a Novel Nucleotide Substitution (HBD: c.442T > C) on the δ-Globin Gene.Transcriptional and posttranscriptional regulation and endocytosis were involved in zinc oxide nanoparticle-induced interleukin-8 overexpression in human bronchial epithelial cells.Rous Sarcoma Virus RNA Stability Element Inhibits Deadenylation of mRNAs with Long 3'UTRs.Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.Globin mRNA reduction for whole-blood transcriptome sequencing.A new β(0)-thalassemia mutation (codon 102, AAC>ATCAC) in coexistence with a heterozygous P4.2 Nippon gene.Identification of a novel mutation in the β-globin gene 3' untranslated region [+1,506 (A>C)] in a Japanese male with a heterozygous β-thalassemia phenotype.A novel single nucleotide deletion mutation in exon 2 (HBB: c240delC) of beta globin gene: A case report.Nanoplasmonic probes of RNA folding and assembly during pre-mRNA splicing.Coinheritance of a novel mutation on the HBA1 gene: c.187delG (p.W62fsX66) [codon 62 (-G) (α1)] with the α212 patchwork allele and Hb S [β6(A3)Glu→Val, GAG>GTG; HBB: c.20A>T].Precise Excision of the CAG Tract from the Huntingtin Gene by Cas9 Nickases.

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Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

http://www.wikidata.org/entity/Q37847790

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 28 February 2011

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@en

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@nl

type

label

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@en

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@nl

prefLabel

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@en

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

@nl

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HAEMATOL.2010.039206

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Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype

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Ana Luísa Silva

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Isabel Peixeiro

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Luísa Romão

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P2860

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

Identification of two KH domain proteins in the alpha-globin mRNP stability complex

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

Structural and functional analysis of an mRNP complex that mediates the high stability of human beta-globin mRNA

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

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scholarly article

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10.3324/HAEMATOL.2010.039206

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