The role of IκB kinase complex in the neurobiology of Huntington's disease.
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Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Laquinimod treatment in the R6/2 mouse model.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington's Disease-Associated Phenotypes In VivoPolyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtinJAK/STAT Signalling in Huntington's Disease Immune Cells.Oxidative Stress and Huntington's Disease: The Good, The Bad, and The Ugly.HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.Brain rust: recent discoveries on the role of oxidative stress in neurodegenerative diseases.Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB.LXR agonists: new potential therapeutic drug for neurodegenerative diseases.Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration.Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases.Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.IKKβ and mutant huntingtin interactions regulate the expression of IL-34: implications for microglial-mediated neurodegeneration in HD.
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The role of IκB kinase complex in the neurobiology of Huntington's disease.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 05 May 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@en
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@nl
type
label
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@en
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@nl
prefLabel
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@en
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@nl
P2860
P1476
The role of IκB kinase complex in the neurobiology of Huntington's disease.
@en
P2093
Ali Khoshnan
Paul H Patterson
P2860
P304
P356
10.1016/J.NBD.2011.04.015
P577
2011-05-05T00:00:00Z