Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
about
The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function.Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11.A peptide-hormone-inactivating endopeptidase in Xenopus laevis skin secretion.Blockade by oral or parenteral RPR 100893 (a non-peptide NK1 receptor antagonist) of neurogenic plasma protein extravasation within guinea-pig dura mater and conjunctiva.Extracellular proteases as targets for drug developmentCellular proteolysis. An overview.Neutral endopeptidase inhibitors and atrial natriuretic peptide.Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".Perspectives in the field of drug metabolism.Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.Role of glycosylation in transport and enzymic activity of neutral endopeptidase-24.11.Secretion of a functional soluble form of neutral endopeptidase-24.11 from a baculovirus-infected insect cell line.Characterization of neutral endopeptidase 24.11 in dog glomeruli.Mutagenesis of Glu403 to Cys in rabbit neutral endopeptidase-24.11 (neprilysin) creates a disulphide-linked homodimer: analogy with endothelin-converting enzyme.Time-dependent blockade of neurogenic plasma extravasation in dura mater by 5-HT1B/D agonists and endopeptidase 24.11.Cloning and expression in Bacillus subtilis of the npr gene from Bacillus thermoproteolyticus Rokko coding for the thermostable metalloprotease thermolysin.In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position.The role of the C-terminal region of rat brain natriuretic peptide in receptor selectivity.
P2860
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P2860
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on June 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@en
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@nl
type
label
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@en
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@nl
prefLabel
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@en
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@nl
P1476
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
@en
P2093
P304
P356
10.1016/0165-6147(90)90252-4
P577
1990-06-01T00:00:00Z