Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme. - Wikidata - awgldk - TriplyDB

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

http://www.wikidata.org/entity/Q40808050

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beta-Amyloid degradation and Alzheimer's disease Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide The Kell protein of the common K2 phenotype is a catalytically active metalloprotease, whereas the rare Kell K1 antigen is inactive. Identification of novel substrates for the Kell protein An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition Mechanisms of Aβ Clearance and Degradation by Glial Cells Diabetes Mellitus Induces Alzheimer's Disease Pathology: Histopathological Evidence from Animal Models Cerebrovascular disease in ageing and Alzheimer's disease Clearance systems in the brain-implications for Alzheimer disease Endothelin-converting enzymes and related metalloproteases in Alzheimer's disease Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 The ubiquitin-proteasome system in Alzheimer's disease β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Alzheimer disease models and human neuropathology: similarities and differences Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease.Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme.Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2 Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.Effects of 4-hydroxy-nonenal and Amyloid-beta on expression and activity of endothelin converting enzyme and insulin degrading enzyme in SH-SY5Y cells.Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro Transgenic Drosophila models of Alzheimer's disease and tauopathies Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity Ginsenoside Rg1 decreases Aβ(1-42) level by upregulating PPARγ and IDE expression in the hippocampus of a rat model of Alzheimer's disease.Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice.Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein The endocytic pathway in microglia during health, aging and Alzheimer's disease.Identification of BACE2 as an avid ß-amyloid-degrading protease

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P2860

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

http://www.wikidata.org/entity/Q40808050

description

2001 nî lūn-bûn

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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2001年论文

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2001年论文

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name

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

@en

type

label

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

@en

prefLabel

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

@en

P1433

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Journal of Biological Chemistry

P1476

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.

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P2093

C B Eckman

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D K Reed

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E A Eckman

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P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells

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24540-24548

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10.1074/JBC.M007579200

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27

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276

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11337485

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Alzheimer's disease