Cancers and the NSD family of histone lysine methyltransferases.
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Identification of druggable cancer driver genes amplified across TCGA datasetsSinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2Histone methyltransferases: novel targets for tumor and developmental defectsThe interplay of histone modifications - writers that readGain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionThe H-factor as a novel quality metric for homology modelingNSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.MMSET: role and therapeutic opportunities in multiple myeloma.Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.Neural crest specification and migration independently require NSD3-related lysine methyltransferase activity.In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.Genetic alterations of histone lysine methyltransferases and their significance in breast cancerHistone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies.Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer.Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites.Role of several histone lysine methyltransferases in tumor development.Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.A Tumor-Specific Neo-Antigen Caused by a Frameshift Mutation in BAP1 Is a Potential Personalized Biomarker in Malignant Peritoneal MesotheliomaTargeted drug discovery for pediatric leukemia.NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion.On your histone mark, SET, methylate!Mind the methyl: methyllysine binding proteins in epigenetic regulation.The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.A sensitive luminescent assay for the histone methyltransferase NSD1 and other SAM-dependent enzymes.Nuclear Protein of the Testis Midline Carcinoma Masquerading as a Primary Mediastinal SeminomaWolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis.Wolf-Hirschhorn syndrome candidate 1-like 1 epigenetically regulates nephrin gene expression.Disruption of NSD1 in head and neck cancer promotes favorable chemotherapeutic responses linked to hypomethylation.Development of a Time-Resolved Fluorescence Resonance Energy Transfer Ultrahigh-Throughput Screening Assay for Targeting the NSD3 and MYC Interaction.The role of histone lysine methyltransferase NSD3 in cancer
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Cancers and the NSD family of histone lysine methyltransferases.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 June 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cancers and the NSD family of histone lysine methyltransferases.
@en
Cancers and the NSD family of histone lysine methyltransferases.
@nl
type
label
Cancers and the NSD family of histone lysine methyltransferases.
@en
Cancers and the NSD family of histone lysine methyltransferases.
@nl
prefLabel
Cancers and the NSD family of histone lysine methyltransferases.
@en
Cancers and the NSD family of histone lysine methyltransferases.
@nl
P1476
Cancers and the NSD family of histone lysine methyltransferases
@en
P2093
Masayo Morishita
P304
P356
10.1016/J.BBCAN.2011.05.004
P407
P577
2011-06-06T00:00:00Z