Assessing atropisomer axial chirality in drug discovery and development.
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Unusual dimeric tetrahydroxanthone derivatives from Aspergillus lentulus and the determination of their axial chiralitiesKinetic barriers in the isomerization of substituted ureas: implications for computer-aided drug designSpontaneous transfer of chirality in an atropisomerically enriched two-axis system.Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L BromodomainsAlterporriol-type dimers from the mangrove endophytic fungus, Alternaria sp. (SK11), and their MptpB inhibitionsOrally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.Regioselective derivatizations of a tribrominated atropisomeric benzamide scaffold.Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activitySmall molecule Hedgehog pathway antagonists.Enantioselective synthesis of atropisomeric benzamides through peptide-catalyzed bromination.Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.Rotational isomers of N-methyl-N-arylacetamides and their derived enolates: implications for asymmetric Hartwig oxindole cyclizations.Proton donor acidity controls selectivity in nonaromatic nitrogen heterocycle synthesis.Enantioselective synthesis of 3-arylquinazolin-4(3H)-ones via peptide-catalyzed atroposelective bromination.Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.Recent trends and applications in liquid-phase chromatography enantioseparation of atropisomers.Ternary copper(II)-polypyridyl enantiomers: aldol-type condensation, characterization, DNA-binding recognition, BSA-binding and anticancer property.Measurement of atropisomer racemization kinetics using segmented flow technology.Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation.Dynamic Behavior of Clobazam on High-Performance Liquid Chromatography Chiral Stationary Phases.Biological and Structural Characterization of Rotamers of C-C Chemokine Receptor Type 5 (CCR5) Inhibitor GSK214096.Synthesis, resolution and crystal structures of two enanti-omeric rhodamine derivatives.Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor.Unprecedented induced axial chirality in a molecular BODIPY dye: strongly bisignated electronic circular dichroism in the visible region.Exploiting Atropisomerism to Increase the Target Selectivity of Kinase Inhibitors.Atropisomerism in medicinal chemistry: challenges and opportunities.Medium-Sized-Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles Ring Expansion.General Enantioselective C-H Activation with Efficiently Tunable Cyclopentadienyl Ligands.Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF-06463922) and Desmethyl Congeners.Separation of atropisomers by chiral liquid chromatography and thermodynamic analysis of separation mechanism.Enantioselective syntheses of atropisomers featuring a five-membered ring.Discovery and Assessment of Atropisomers of (±)-Lesinurad.Aromatic amide-derived non-biaryl atropisomers as highly efficient ligands in silver-catalyzed asymmetric cycloaddition reactions.Novel naphthylpyridines from cobalt-catalyzed cyclotrimerization of a chiral diyne.Divergent Control of Point and Axial Stereogenicity: Catalytic Enantioselective C-N Bond-Forming Cross-Coupling and Catalyst-Controlled Atroposelective Cyclodehydration.N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived ActinomyceteCombining Organocatalysis with Central-to-Axial Chirality Conversion: Atroposelective Hantzsch-Type Synthesis of 4-Arylpyridines.Induction of chirality: experimental evidence of atropisomerism in azapeptides.Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution.
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P2860
Assessing atropisomer axial chirality in drug discovery and development.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Assessing atropisomer axial chirality in drug discovery and development.
@en
Assessing atropisomer axial chirality in drug discovery and development.
@nl
type
label
Assessing atropisomer axial chirality in drug discovery and development.
@en
Assessing atropisomer axial chirality in drug discovery and development.
@nl
prefLabel
Assessing atropisomer axial chirality in drug discovery and development.
@en
Assessing atropisomer axial chirality in drug discovery and development.
@nl
P2093
P356
P1476
Assessing atropisomer axial chirality in drug discovery and development.
@en
P2093
Daniel R Fandrick
Keith R Fandrick
Lee D Fader
Oliver Hucke
Paul J Edwards
Ray Kemper
Stephen P F Miller
Steven R Laplante
P304
P356
10.1021/JM200584G
P407
P577
2011-09-15T00:00:00Z