Genetic and mutational analysis of the T-cell antigen receptor.
about
NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signalingThe CD3-gamma and CD3-delta subunits of the T cell antigen receptor can be expressed within distinct functional TCR/CD3 complexesStructure and dynamic properties of membrane proteins using NMR.The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiologyIntimate association of Thy-1 and the T-cell antigen receptor with the CD45 tyrosine phosphatase.Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell developmentSignal transduction by T-cell receptors: mobilization of Ca and regulation of Ca-dependent effector molecules.Butyric acid-induced apoptosis of murine thymocytes, splenic T cells, and human Jurkat T cells.Binding of soluble natural ligands to a soluble human T-cell receptor fragment produced in Escherichia coli.A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E geneEnhanced replication of human T-cell leukemia virus type 1 in T cells from transgenic rats expressing human CRM1 that is regulated in a natural manner.A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.A general method for facilitating heterodimeric pairing between two proteins: application to expression of alpha and beta T-cell receptor extracellular segments.Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma.Functional three-domain single-chain T-cell receptorsFunctional differentiation of T cells in the intestine of T cell receptor transgenic mice.T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha.Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytesRequirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signalingCD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells.Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosisDomains of the TCR beta-chain required for early thymocyte development.Involvement of the TCR Cbeta FG loop in thymic selection and T cell function.Signaling efficiency of the T cell receptor controlled by a single amino acid in the beta chain constant region.Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivoOne of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop.CD3-epsilon overexpressed in prothymocytes acts as an oncogene.Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-rasT cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates.Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.Similarity between fluorescein-specific T-cell receptor and antibody in chemical details of antigen recognition.Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the zeta chain.Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.Evidence for a preformed transducer complex organized by the B cell antigen receptor.Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms
P2860
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P2860
Genetic and mutational analysis of the T-cell antigen receptor.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Genetic and mutational analysis of the T-cell antigen receptor.
@en
Genetic and mutational analysis of the T-cell antigen receptor.
@nl
type
label
Genetic and mutational analysis of the T-cell antigen receptor.
@en
Genetic and mutational analysis of the T-cell antigen receptor.
@nl
prefLabel
Genetic and mutational analysis of the T-cell antigen receptor.
@en
Genetic and mutational analysis of the T-cell antigen receptor.
@nl
P1476
Genetic and mutational analysis of the T-cell antigen receptor.
@en
P2093
Ashwell JD
Klusner RD
P304
P356
10.1146/ANNUREV.IY.08.040190.001035
P577
1990-01-01T00:00:00Z