Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.
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Regulatory motifs in Chk1Targeting the Checkpoint to Kill Cancer CellsZygotic genome activation during the maternal-to-zygotic transitionATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancersRhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damageCheckpoint kinase 1 in DNA damage response and cell cycle regulationControl of cell cycle transcription during G1 and S phasesCombinations of Kinase Inhibitors Protecting Myoblasts against HypoxiaTargeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma CellsHigh expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients.The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemiaCombined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapyWEE1 tyrosine kinase, a novel epigenetic modifierCauses and consequences of replication stress.The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition.HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells.A whole-genome RNA interference screen for human cell factors affecting myxoma virus replicationHistone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.A genome-wide siRNA screen to identify host factors necessary for growth of the parasite Toxoplasma gondii.ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.Targeting lung cancer through inhibition of checkpoint kinases.The fork and the kinase: a DNA replication tale from a CHK1 perspective.A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations.Adenovirus replaces mitotic checkpoint controls.Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphomaCombined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma.LAMMER kinase contributes to genome stability in Ustilago maydis.E2F1 and E2F2 prevent replicative stress and subsequent p53-dependent organ involution.Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase.Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistanceCCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs.Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells.Combination therapy targeting the Chk1 and Wee1 kinases shows therapeutic efficacy in neuroblastoma.Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblastsThe clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis.Senataxin controls meiotic silencing through ATR activation and chromatin remodeling.
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P2860
Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.
description
article científic
@ca
article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
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artigo científico
@pt
artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Safeguarding genome integrity: ...... during normal DNA replication.
@en
Safeguarding genome integrity: ...... during normal DNA replication.
@nl
type
label
Safeguarding genome integrity: ...... during normal DNA replication.
@en
Safeguarding genome integrity: ...... during normal DNA replication.
@nl
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Safeguarding genome integrity: ...... during normal DNA replication.
@en
Safeguarding genome integrity: ...... during normal DNA replication.
@nl
P2860
P921
P356
P1476
Safeguarding genome integrity: ...... during normal DNA replication.
@en
P2093
Claus Storgaard Sørensen
Randi G Syljuåsen
P2860
P304
P356
10.1093/NAR/GKR697
P407
P577
2011-09-21T00:00:00Z
2012-01-01T00:00:00Z