Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
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Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinExpanding proteostasis by membrane trafficking networksStructural Basis for Ovarian Tumor Domain-containing Protein 1 (OTU1) Binding to p97/Valosin-containing Protein (VCP)UBXD Proteins: A Family of Proteins with Diverse Functions in CancerControl of p97 function by cofactor bindingStructural Details of Ufd1 Binding to p97 and Their Functional Implications in ER-Associated DegradationThe N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPaseDegradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48.p97 complexes as signal integration hubs.ATP binding to p97/VCP D1 domain regulates selective recruitment of adaptors to its proximal N-domain.TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switchingEndoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocationChromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Role of p97/VCP (Cdc48) in genome stability.p97 Composition Changes Caused by Allosteric Inhibition Are Suppressed by an On-Target Mechanism that Increases the Enzyme's ATPase Activity.Cdc48 chaperone and adaptor Ubx4 distribute the proteasome in the nucleus for anaphase proteolysis.E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosisCUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosisThe p97-FAF1 protein complex reveals a common mode of p97 adaptor binding.Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition.The AAA+ ATPase p97, a cellular multitool.Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiaeValosin-containing protein (VCP/p97) is capable of unfolding polyubiquitinated proteins through its ATPase domains.Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.Evaluating p97 Inhibitor Analogues for Potency against p97-p37 and p97-Npl4-Ufd1 Complexes.
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P2860
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artículo científico
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Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
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Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
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Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
@en
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
@nl
prefLabel
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
@en
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family.
@nl
P50
P1476
Regulation of p97 in the ubiquitin-proteasome system by the UBX protein-family
@en
P2093
Caroline A Ewens
Patrik Kloppsteck
P304
P356
10.1016/J.BBAMCR.2011.09.006
P407
P577
2011-09-22T00:00:00Z