Epigenetic drug discovery: targeting DNA methyltransferases. - Wikidata - awgldk - TriplyDB

Epigenetic drug discovery: targeting DNA methyltransferases.

Epigenetic drug discovery: targeting DNA methyltransferases.

http://www.wikidata.org/entity/Q37941536

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Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies Epigenetic control of HIV-1 post integration latency: implications for therapy Evidence for the involvement of epigenetics in the progression of renal fibrogenesis Trials with 'epigenetic' drugs: an update Epigenetic modulators as therapeutic targets in prostate cancer Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion 5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching HEDD: the human epigenetic drug database Transcriptional repressor domain of MBD1 is intrinsically disordered and interacts with its binding partners in a selective manner Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies.Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells Perspectives on the discovery of small-molecule modulators for epigenetic processes.Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease Time-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2.Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients.DNA Methylation Modulates Nociceptive Sensitization after Incision.Molecular Subtype-Specific Expression of MicroRNA-29c in Breast Cancer Is Associated with CpG Dinucleotide Methylation of the Promoter Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.Acquired resistance to decitabine and cross-resistance to gemcitabine during the long-term treatment of human HCT116 colorectal cancer cells with decitabine.TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells.Epigenetic mechanisms in commonly occurring cancers.Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells Molecular characteristics and chromatin texture features in acute promyelocytic leukemia.Epigenetics as a therapeutic target in breast cancer.Distinctive Roles of 5-aza-2'-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.Epigenetics and colorectal cancer pathogenesis Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth Genistein mediates the selective radiosensitizing effect in NSCLC A549 cells via inhibiting methylation of the keap1 gene promoter region Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences.The role of promoter hypermethylation in fibroblast activation and fibrogenesis.Drugging the undruggable: transcription therapy for cancer.Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas.Epigenetic regulation of cell signaling pathways in acute lymphoblastic leukemia.Rationalization of activity cliffs of a sulfonamide inhibitor of DNA methyltransferases with induced-fit docking.SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases.Driver mutations of cancer epigenomes.

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P2860

Epigenetic drug discovery: targeting DNA methyltransferases.

http://www.wikidata.org/entity/Q37941536

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Epigenetic drug discovery: targeting DNA methyltransferases.

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Epigenetic drug discovery: targeting DNA methyltransferases.

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Epigenetic drug discovery: targeting DNA methyltransferases.

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Epigenetic drug discovery: targeting DNA methyltransferases.

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Epigenetic drug discovery: targeting DNA methyltransferases.

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Epigenetic drug discovery: targeting DNA methyltransferases.

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1087057111421212

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Journal of Biomolecular Screening

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Epigenetic drug discovery: targeting DNA methyltransferases.

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P2093

Jason M Foulks

http://www.w3.org/2001/XMLSchema#string

K Mark Parnell

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Kevin Wright

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Koc-Kan Ho

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Krzysztof Swierczek

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Michael Saunders

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Michael V McCullar

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Rebecca N Nix

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Steven B Kanner

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Suzanna Chau

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P2860

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

Crystal structure of the nucleosome core particle at 2.8 A resolution

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2

UHRF1 plays a role in maintaining DNA methylation in mammalian cells

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases

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10.1177/1087057111421212

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1

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17

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2011-09-30T00:00:00Z

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51686460

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21965114

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