Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.
about
Molecular view of an electron transfer process essential for iron-sulfur protein biogenesisNADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome cSingle-molecule spectroscopy reveals how calmodulin activates NO synthase by controlling its conformational fluctuation dynamics.The evolution of our understanding of endo-xenobiotic crosstalk and cytochrome P450 regulation and the therapeutic implications.Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function.Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.Kinetic analysis of cytochrome P450 reductase from Artemisia annua reveals accelerated rates of NADH-dependent flavin reduction.Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.
P2860
Q27677438-2010B809-9AEB-45B8-A485-E7B7E91064C8Q30537968-F61F47C3-53F8-45D7-85AB-2C6BBB6385A8Q34577168-239A6D0E-F89E-4001-BCEF-930E3CBD5618Q35755388-996EEA74-1896-4FB2-B4C3-879A33BAFF5BQ36103003-D045DE23-69AD-402E-AB84-1DF7E46A13BAQ38128592-7756F54E-B15F-490F-8A5E-14EF0A2EF7A5Q39012305-273593F1-8E32-447E-B7C9-136F23E91ADDQ42725750-20CB26B2-4886-4DC6-926B-E9DFA1F8F0AEQ46964325-D9028665-9A58-43D1-96DD-7011FCA1967BQ51125003-D1247B7B-0E12-4A04-B757-D35D71FE94C7
P2860
Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@en
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@nl
type
label
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@en
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@nl
prefLabel
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@en
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@nl
P2093
P2860
P50
P1433
P1476
Kinetic and spectroscopic prob ...... 0 reductase family of enzymes.
@en
P2093
Basile Khara
Nigel S Scrutton
Stephen E J Rigby
P2860
P304
P356
10.1111/J.1742-4658.2011.08442.X
P407
P577
2012-01-09T00:00:00Z