Regulating the regulator: post-translational modification of RAS
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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP114-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteinsKRAS Mutant Pancreatic Cancer: No Lone Path to an Effective TreatmentThe Significance of Ras Activity in Pancreatic Cancer InitiationSimilar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistanceChemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative MedicineMass spectrometry-based detection and assignment of protein posttranslational modificationsSmall G proteins in the cardiovascular system: physiological and pathological aspectsMolecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage responseThe physiology of protein S-acylationNutrient regulation of the mTOR complex 1 signaling pathway2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activitiesMechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1Brassinosteroid signaling and BRI1 dynamics went undergroundRAS isoforms and mutations in cancer at a glanceRas inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosisThe Molecular Mechanism Underlying Recruitment and Insertion of Lipid-Anchored LC3 Protein into MembranesPrenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoformTowards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiaeIdentification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI bindingMenin determines K-RAS proliferative outputs in endocrine cellsMsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidationWIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.H-Ras forms dimers on membrane surfaces via a protein-protein interface.A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochoresIndividual S-acylated cysteines differentially contribute to H-Ras endomembrane trafficking and acylation/deacylation cycles.Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathwayMAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance.Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.A high-throughput assay for small molecule destabilizers of the KRAS oncoproteinBiomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRASAn improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.H-Ras regulation of TRAIL death receptor mediated apoptosisPolyisoprenylated methylated protein methyl esterase: a putative biomarker and therapeutic target for pancreatic cancerWhen ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Ral small GTPase signaling and oncogenesis: More than just 15minutes of fameNRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemiaK-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motifTransformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation
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P2860
Regulating the regulator: post-translational modification of RAS
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Regulating the regulator: post-translational modification of RAS
@en
Regulating the regulator: post-translational modification of RAS.
@nl
type
label
Regulating the regulator: post-translational modification of RAS
@en
Regulating the regulator: post-translational modification of RAS.
@nl
prefLabel
Regulating the regulator: post-translational modification of RAS
@en
Regulating the regulator: post-translational modification of RAS.
@nl
P2093
P2860
P356
P1476
Regulating the regulator: post-translational modification of RAS
@en
P2093
Ian M Ahearn
Kevin Haigis
Mark R Philips
P2860
P2888
P356
10.1038/NRM3255
P577
2011-12-22T00:00:00Z