Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
about
Structure of a proteolytically resistant analogue of (NLys)5SFTI-1 in complex with trypsin: evidence for the direct participation of the Ser214 carbonyl group in serine protease-mediated proteolysisInvestigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1)Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization.Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1.Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1Click-Based Libraries of SFTI-1 Peptides: New Methods Using Reversed-Phase Silica.Efficient recombinant expression of SFTI-1 in bacterial cells using intein-mediated protein trans-splicing.Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3Noncovalent inhibitors of human 20S and 26S proteasome based on trypsin inhibitor SFTI-1.Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations.Peptide bicycles that inhibit the Grb2 SH2 domain.Between two worlds: a comparative study on in vitro and in silico inhibition of trypsin and matriptase by redox-stable SFTI-1 variants at near physiological pH.Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds.Crystal structure of plant legumain reveals a unique two-chain state with pH-dependent activity regulation.Sortase A-mediated synthesis of ligand-grafted cyclized peptides for modulating a model protein-protein interaction.Structural analyses of Arabidopsis thaliana legumain γ reveal the differential recognition and processing of proteolysis and ligation substrates.Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P₁ positions by peptoid monomers.
P2860
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P2860
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
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article científic
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article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@en
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
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type
label
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@en
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@nl
prefLabel
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@en
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@nl
P50
P1476
Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.
@en
P304
P356
10.2174/138161211798999393
P577
2011-12-01T00:00:00Z