about
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.Biochemical and structural characterization of SplD protease from Staphylococcus aureusCathepsin G activity lowers plasma LDL and reduces atherosclerosisStructural and Functional Analysis of Human HtrA3 Protease and Its SubdomainsSynthesis and Evaluation of Biological Activity of Antimicrobial--Pro-Proliferative Peptide ConjugatesThe LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.Development of sensitive cathepsin G fluorogenic substrate using combinatorial chemistry methods.The influence of substrate peptide length on human beta-tryptase specificity.Selection of peptomeric inhibitors of bovine alpha-chymotrypsin and cathepsin G based on trypsin inhibitor SFTI-1 using a combinatorial chemistry approach.Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum.Substrate specificity and inhibitory study of human airway trypsin-like protease.Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C.Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity.Microarray analysis of differentially expressed genes in cells resistant to HIV-1.A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.Substrate specificity of human matriptase-2.Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1Design and synthesis of new substrates of HtrA2 protease.Analysis of the link between the redox state and enzymatic activity of the HtrA (DegP) protein from Escherichia coli.PEGylated substrates of NSP4 protease: A tool to study protease specificity.Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G.Temperature-induced changes of HtrA2(Omi) protease activity and structureSunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.Future of protease activity assays.Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).Inhibitors of cathepsin G: a patent review (2005 to present).A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer.Surface plasmon resonance imaging biosensor for cathepsin G based on a potent inhibitor: development and applications.Simplified, serine-rich theta-defensin analogues as antitumour peptides.Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.Ultrasensitive internally quenched substrates of human cathepsin L.Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin.Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection.
P50
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P50
description
Polish researcher, chemist
@en
polski chemik
@pl
wetenschapper
@nl
հետազոտող
@hy
name
Adam Lesner
@ast
Adam Lesner
@en
Adam Lesner
@es
Adam Lesner
@nl
Adam Lesner
@pl
type
label
Adam Lesner
@ast
Adam Lesner
@en
Adam Lesner
@es
Adam Lesner
@nl
Adam Lesner
@pl
altLabel
Adam Jerzy Lesner
@pl
prefLabel
Adam Lesner
@ast
Adam Lesner
@en
Adam Lesner
@es
Adam Lesner
@nl
Adam Lesner
@pl
P106
P1153
6602489279
P2038
Adam_Lesner
P21
P31
P3124
P496
0000-0001-8335-3431