Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
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Newly discovered angiogenesis inhibitors and their mechanisms of actionDemethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB PathwayNew Abietane and Kaurane Type Diterpenoids from the Stems of Tripterygium regeliiAccurate mass-time tag library for LC/MS-based metabolite profiling of medicinal plantsActivation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats.Protective Effect of 18β-Glycyrrhetinic Acid against Triptolide-Induced Hepatotoxicity in Rats.Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells.Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explainPhosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation.Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency.Triptolide ameliorates colonic fibrosis in an experimental rat modelTanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and tumor cellsStrategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Lipophilic stinging nettle extracts possess potent anti-inflammatory activity, are not cytotoxic and may be superior to traditional tinctures for treating inflammatory disorders.Triptolide Transcriptionally Represses HER2 in Ovarian Cancer Cells by Targeting NF-κBTherapeutic use of traditional Chinese herbal medications for chronic kidney diseasesTriptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors.Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation.Nanostructured lipid carriers as a novel oral delivery system for triptolide: induced changes in pharmacokinetics profile associated with reduced toxicity in male rats.Codelivery of doxorubicin and triptolide with reduction-sensitive lipid-polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment.Triptolide with potential medicinal value for diseases of the central nervous system.Perspectives on natural product epigenetic modulators in chemical biology and medicine.Diterpenoids of terrestrial origin.Pharmacological modulation of anti-tumor immunity induced by oncolytic viruses.Natural product and natural product derived drugs in clinical trials.Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy.Aromatic abietane diterpenoids: their biological activity and synthesis.Catalytic asymmetric synthesis of enantioenriched heterocycles bearing a C-CF3 stereogenic center.Biosynthesis of Diterpenoids in Tripterygium Adventitious Root Cultures.Production of Putative Diterpene Carboxylic Acid Intermediates of Triptolide in Yeast.Triptolide inhibits the growth of osteosarcoma by regulating microRNA-181a via targeting PTEN gene in vivo and vitro.Covalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolideTriptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells.The structural modification of natural products for novel drug discovery.Targeting acute myeloid leukemia stem cell signaling by natural products.Chalcone: A Privileged Structure in Medicinal Chemistry.Compounds From Celastraceae Targeting Cancer Pathways and Their Potential Application in Head and Neck Squamous Cell Carcinoma: A Review.
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P2860
Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
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artículo científico
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name
Triptolide: structural modific ...... al development and mechanisms.
@en
Triptolide: structural modific ...... al development and mechanisms.
@nl
type
label
Triptolide: structural modific ...... al development and mechanisms.
@en
Triptolide: structural modific ...... al development and mechanisms.
@nl
prefLabel
Triptolide: structural modific ...... al development and mechanisms.
@en
Triptolide: structural modific ...... al development and mechanisms.
@nl
P2093
P2860
P356
P1476
Triptolide: structural modific ...... al development and mechanisms.
@en
P2093
Ya-Xi Yang
Yuan-Chao Li
Ze-Hong Miao
Zhao-Li Zhou
P2860
P304
P356
10.1039/C2NP00088A
P577
2012-01-23T00:00:00Z