Progranulin axis and recent developments in frontotemporal lobar degeneration
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PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistanceImpaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutationsAdministration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner.Lysosomal processing of progranulinGenetics of Frontotemporal Dementia.The Genetics of Monogenic Frontotemporal Dementia.Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C.Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
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Progranulin axis and recent developments in frontotemporal lobar degeneration
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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Progranulin axis and recent developments in frontotemporal lobar degeneration
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Progranulin axis and recent developments in frontotemporal lobar degeneration.
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label
Progranulin axis and recent developments in frontotemporal lobar degeneration
@en
Progranulin axis and recent developments in frontotemporal lobar degeneration.
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Progranulin axis and recent developments in frontotemporal lobar degeneration
@en
Progranulin axis and recent developments in frontotemporal lobar degeneration.
@nl
P2860
P356
P1476
Progranulin axis and recent developments in frontotemporal lobar degeneration
@en
P2093
Alexandra M Nicholson
Jennifer Gass
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P2888
P356
10.1186/ALZRT102
P407
P577
2012-01-23T00:00:00Z
P5875
P6179
1010835750