Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for α(1)-microglobulin.
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Extracellular hemoglobin: the case of a friend turned foeProteomics analysis of the peritoneal dialysate effluent reveals the presence of calcium-regulation proteins and acute inflammatory response.Characterization of heme binding to recombinant α1-microglobulin.Molecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin.A1M/α1-microglobulin is proteolytically activated by myeloperoxidase, binds its heme group and inhibits low density lipoprotein oxidation.Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Blood substitutes: why haven't we been more successful?The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators.Response of Neutrophils to Extracellular Haemoglobin and LTA in Human Blood SystemMechanisms of group A Streptococcus resistance to reactive oxygen species.Biodistribution and pharmacokinetics of recombinant α1-microglobulin and its potential use in radioprotection of kidneys.Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage?Cell-free hemoglobin: a novel mediator of acute lung injuryNovel hematopoietic target genes in the NRF2-mediated transcriptional pathway.A1M/α1-microglobulin protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia.First trimester prediction of preeclampsia.The roles of NRF2 in modulating cellular iron homeostasis.Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.Novel insights into the pathophysiology and clinical aspects of diabetic nephropathy.The Role of Mitochondria, Oxidative Stress, and the Radical-binding Protein A1M in Cultured Porcine Retina.Cardiopulmonary bypass in the newborn: effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model.Alpha1-microglobulin as an early biomarker of sepsis-associated acute kidney injury: a prospective cohort study.Extracellular fetal hemoglobin induces increases in glomerular permeability: inhibition with α1-microglobulin and tempol.The cysteine 34 residue of A1M/α1-microglobulin is essential for protection of irradiated cell cultures and reduction of carbonyl groups.Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats.Characterization of Renal Injury and Inflammation in an Experimental Model of Intravascular Hemolysis.The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin.High level of serum AMBP is associated with poor response to paclitaxel-capecitabine chemotherapy in advanced gastric cancer patients.Prospects for early investigational therapies for sickle cell disease.Possibilities of Using Fetal Hemoglobin as a Platform for Producing Hemoglobin-Based Oxygen Carriers (HBOCs).Haptoglobin 2-2 genotype is associated with presence and progression of MRI depicted atherosclerotic intraplaque hemorrhage.
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Pathological conditions involving extracellular hemoglobin: molecular mechanisms, clinical significance, and novel therapeutic opportunities for α(1)-microglobulin.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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Pathological conditions involv ...... nities for α(1)-microglobulin.
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Pathological conditions involv ...... nities for α(1)-microglobulin.
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type
label
Pathological conditions involv ...... nities for α(1)-microglobulin.
@en
Pathological conditions involv ...... nities for α(1)-microglobulin.
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Pathological conditions involv ...... nities for α(1)-microglobulin.
@en
Pathological conditions involv ...... nities for α(1)-microglobulin.
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P2093
P356
P1476
Pathological conditions involv ...... nities for α(1)-microglobulin.
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P2093
Artur Schmidtchen
Bo Akerström
Leif Bülow
Magnus G Olsson
Maria Allhorn
Martin L Olsson
Stefan R Hansson
P304
P356
10.1089/ARS.2011.4282
P577
2012-03-23T00:00:00Z