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Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionMultifaceted roles of STIM proteinsTwo-pore channels at the intersection of endolysosomal membrane trafficDomain assembly of NAADP-gated two-pore channelsHigh resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heartFunction and dysfunction of two-pore channels.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Calcium pathway machinery at fertilization in echinodermsNAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.Poring over two-pore channel pore mutants.Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.Questioning regulation of two-pore channels by NAADPTwo pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
NAADP on target.
@en
NAADP on target.
@nl
type
label
NAADP on target.
@en
NAADP on target.
@nl
prefLabel
NAADP on target.
@en
NAADP on target.
@nl
P1476
NAADP on target.
@en
P2093
Robert Hooper
P304
P356
10.1007/978-94-007-2888-2_14
P407
P50
P577
2012-01-01T00:00:00Z