New insights from structural biology into the druggability of G protein-coupled receptors.
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Atypical regulation of G protein-coupled receptor intracellular trafficking by ubiquitinationBiophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug DesignThe 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorG-Protein/β-Arrestin-Linked Fluctuating Network of G-Protein-Coupled Receptors for Predicting Drug Efficacy and Bias Using Short-Term Molecular Dynamics SimulationInvited review: GPCR structural characterization: Using fragments as building blocks to determine a complete structure.Beyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at WorkNative phasing of x-ray free-electron laser data for a G protein-coupled receptor.Scents and sense: in silico perspectives on olfactory receptors.An unbiased method to build benchmarking sets for ligand-based virtual screening and its application to GPCRsRearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptorsStructure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid ReceptorEndothelial C-type natriuretic peptide maintains vascular homeostasis.Insights into the structure of class B GPCRs.Structural Analysis of Chemokine Receptor-Ligand Interactions.G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.Guided reconstitution of membrane protein fragmentsStructure-based design of small-molecule ligands of phosphofructokinase-2 activating or inhibiting glycolysis.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Complete Reversible Refolding of a G-Protein Coupled Receptor on a Solid Support.ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.Scaling the druggability landscape of human bromodomains, a new class of drug targets.Ubiquitination of G protein-coupled receptors: functional implications and drug discovery.The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting.How Can Mutations Thermostabilize G-Protein-Coupled Receptors?Minireview: ubiquitination-regulated G protein-coupled receptor signaling and traffickingA synthetic bivalent ligand of CXCR4 inhibits HIV infectionNovel insights on thyroid-stimulating hormone receptor signal transduction.A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35Clustered distribution of natural product leads of drugs in the chemical space as influenced by the privileged target-sites.Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach.Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists.Structure-based and fragment-based GPCR drug discovery.Structure of Class B GPCRs: new horizons for drug discovery.Tuning up the right signal: chemical and genetic approaches to study GPCR functions.The impact of binding thermodynamics on medicinal chemistry optimizations.In silico design of novel probes for the atypical opioid receptor MRGPRX2.Paralog-divergent Features May Help Reduce Off-target Effects of Drugs: Hints from Glucagon Subfamily Analysis.
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P2860
New insights from structural biology into the druggability of G protein-coupled receptors.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
New insights from structural b ...... f G protein-coupled receptors.
@en
New insights from structural b ...... f G protein-coupled receptors.
@nl
type
label
New insights from structural b ...... f G protein-coupled receptors.
@en
New insights from structural b ...... f G protein-coupled receptors.
@nl
prefLabel
New insights from structural b ...... f G protein-coupled receptors.
@en
New insights from structural b ...... f G protein-coupled receptors.
@nl
P2093
P1476
New insights from structural biology into the druggability of G protein-coupled receptors
@en
P2093
Andrea Bortolato
Jonathan S Mason
Miles Congreve
P304
P356
10.1016/J.TIPS.2012.02.005
P577
2012-03-30T00:00:00Z