The advent of AAV9 expands applications for brain and spinal cord gene delivery.
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Biology of adeno-associated viral vectors in the central nervous systemTargeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasoundSelective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis.Glial promoter selectivity following AAV-delivery to the immature brain.Systemic gene delivery to the central nervous system using Adeno-associated virus.Biodistribution of adeno-associated virus serotype 9 (AAV9) vector after intrathecal and intravenous delivery in mouseBiochemical and Physiological Improvement in a Mouse Model of Smith-Lemli-Opitz Syndrome (SLOS) Following Gene Transfer with AAV Vectors.In vivo reprogramming of adult somatic cells to pluripotency by overexpression of Yamanaka factors.Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling.Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.Advances in therapeutic development for spinal muscular atrophy.Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates.Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.Gene therapy approaches for lysosomal storage disease: next-generation treatment.Strategies to circumvent humoral immunity to adeno-associated viral vectors.AAV9-mediated central nervous system-targeted gene delivery via cisterna magna route in mice.Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9.Preservation of forelimb function by UPF1 gene therapy in a rat model of TDP-43-induced motor paralysis.Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.Recombinant adeno-associated virus vectors in the treatment of rare diseases.Adeno-associated virus serotypes 9 and rh10 mediate strong neuronal transduction of the dog brain.Antioxidant gene therapy against neuronal cell death.A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting.Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration.Spinal cord injury induced neuropathic pain: Molecular targets and therapeutic approaches.Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes.Synergistic effects of treating the spinal cord and brain in CLN1 disease.The role of growth factors as a therapeutic approach to demyelinating disease.Gene Therapeutic Reversal of Peripheral Olfactory Impairment in Bardet-Biedl Syndrome.Perspective on innovative therapies for globoid cell leukodystrophy.Improved gene delivery to adult mouse spinal cord through the use of engineered hybrid adeno-associated viral serotypes.Intramuscular Delivery of scAAV9-hIGF1 Prolongs Survival in the hSOD1G93A ALS Mouse Model via Upregulation of D-Amino Acid Oxidase.Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update.Development of an AAV9 coding for a 3XFLAG-TALEfrat#8-VP64 able to increase in vivo the human frataxin in YG8R mice.Intracerebroventricular delivery of self-complementary adeno-associated virus serotype 9 to the adult rat brain.Injection parameters and virus dependent choice of promoters to improve neuron targeting in the nonhuman primate brain.Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons.Mouse gender influences brain transduction by intravascularly administered AAV9.Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome.
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The advent of AAV9 expands applications for brain and spinal cord gene delivery.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
The advent of AAV9 expands applications for brain and spinal cord gene delivery.
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type
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The advent of AAV9 expands applications for brain and spinal cord gene delivery.
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prefLabel
The advent of AAV9 expands applications for brain and spinal cord gene delivery.
@en
P2093
P2860
P1476
The advent of AAV9 expands applications for brain and spinal cord gene delivery.
@en
P2093
David B Wang
Robert D Dayton
Ronald L Klein
P2860
P304
P356
10.1517/14712598.2012.681463
P407
P577
2012-04-20T00:00:00Z