Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.
about
Challenges and advances in the assessment of the disposition of antibody-drug conjugatesMechanistic and quantitative insight into cell surface targeted molecular imaging agent design.Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptorTracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance.Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes.Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokineticsPreclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor.The combination of trastuzumab and pertuzumab administered at approved doses may delay development of trastuzumab resistance by additively enhancing antibody-dependent cell-mediated cytotoxicity.Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.ADME of monoclonal antibody biotherapeutics: knowledge gaps and emerging tools.Assessments of antibody biodistribution.An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.Antibody-Drug Conjugates as Cancer Therapeutics: Past, Present, and Future.Pharmacokinetic Considerations for Antibody-Drug Conjugates against Cancer.Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches.Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.
P2860
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P2860
Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
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artikull shkencor
@sq
artículo científico
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name
Compartmental tissue distribut ...... pproaches and interpretations.
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type
label
Compartmental tissue distribut ...... pproaches and interpretations.
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prefLabel
Compartmental tissue distribut ...... pproaches and interpretations.
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P2093
P2860
P1433
P1476
Compartmental tissue distribut ...... approaches and interpretations
@en
P2093
Daniela Bumbaca
Leslie A Khawli
Paul J Fielder
P2860
P2888
P304
P356
10.1208/S12248-012-9374-1
P407
P50
P577
2012-05-31T00:00:00Z
P5875
P6179
1002839940