Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

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Liquid Chromatography-Mass Spectrometry/Mass Spectrometry Analysis and Pharmacokinetic Assessment of Ponatinib in Sprague-Dawley Rats.Deciphering the In Vivo Performance of a Monoclonal Antibody to Neutralize Its Soluble Target at the Site of Action in a Mouse Collagen-Induced Arthritis Model.

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P2860

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

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2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Dose dependent pharmacokinetic ...... antibody against DLL4 in mice.

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Amrita V Kamath

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Ben-Quan Shen

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Daniela Bumbaca

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Glenn Pacheco

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Joni Castro

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Leslie Khawli

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Lisa A Damico-Beyer

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Minhong Yan

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Peter Haughney

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Priyanka Gupta

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P2860

Dll4, a novel Notch ligand expressed in arterial endothelium

Notch signaling: cell fate control and signal integration in development

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Dosage-sensitive requirement for mouse Dll4 in artery development

Notch signalling: a simple pathway becomes complex

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis.

Notch signaling in vascular development.

Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice

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1631-1637

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scholarly article

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10.4161/MABS.36107

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C A Boswell

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Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

about

P2860

P2860

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice.

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