Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
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Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotypeMonogenic hypercholesterolemia: new insights in pathogenesis and treatmentFamilial hypercholesterolemia in St-Petersburg: the known and novel mutations found in the low density lipoprotein receptor gene in RussiaHypercholesterolemia and apolipoprotein B expression: regulation by selenium status.Familial hypercholesterolemia: present and future managementAntagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 CellsStructural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptorAccumulation of "small dense" low density lipoproteins (LDL) in a homozygous patients with familial defective apolipoprotein B-100 results from heterogenous interaction of LDL subfractions with the LDL receptor.Transgenic mice expressing high levels of human apolipoprotein B develop severe atherosclerotic lesions in response to a high-fat diet.A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol.Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genesThe mechanisms of genome-wide target gene regulation by TCF7L2 in liver cellsHuman prions and plasma lipoproteins.Sequence diversity in genes of lipid metabolismThe genetics of familial hypercholesterolemia and emerging therapiesGenetic diagnosis of familial hypercholesterolaemia by targeted next-generation sequencing.The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5)Familial ligand-defective apolipoprotein B. Identification of a new mutation that decreases LDL receptor binding affinity.Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian populationAre centenarians genetically predisposed to lower disease risk?Molecular basis of familial hypercholesterolemia: An Indian experienceEpitopes close to the apolipoprotein B low density lipoprotein receptor-binding site are modified by advanced glycation end productsLow density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation.Common and rare gene variants affecting plasma LDL cholesterolGenetic variation and atherosclerosis.Familial hypercholesterolaemia: pilot study to identify children at riskDecreased bone mineral density in subjects carrying familial defective apolipoprotein B-100.Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization.Mutagenically separated PCR (MS-PCR): a highly specific one step procedure for easy mutation detection.Familial defective apolipoprotein B-100: a cause of hypercholesterolemia and early coronary heart disease.A versatile and tunable coating strategy allows control of nanocrystal delivery to cell types in the liver.Biological Effect of Cynara cardunculus on Kidney Status of Hypercholesterolemic Rats.Usefulness of the genetic risk score to identify phenocopies in families with familial hypercholesterolemia?Can modulators of apolipoproteinB biogenesis serve as an alternate target for cholesterol-lowering drugs?GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease.
P2860
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P2860
Familial defective apolipoprotein B-100: a mutation of apolipoprotein B that causes hypercholesterolemia.
description
article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
@id
artikull shkencor
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artículo científico
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name
Familial defective apolipoprot ...... t causes hypercholesterolemia.
@en
type
label
Familial defective apolipoprot ...... t causes hypercholesterolemia.
@en
prefLabel
Familial defective apolipoprot ...... t causes hypercholesterolemia.
@en
P2093
P1476
Familial defective apolipoprot ...... t causes hypercholesterolemia.
@en
P2093
Davignon J
Innerarity TL
McCarthy BJ
Weisgraber KH
P304
P577
1990-08-01T00:00:00Z