Scission of the p53-MDM2 Loop by Ribosomal Proteins. - Wikidata - awgldk - TriplyDB

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

http://www.wikidata.org/entity/Q38059701

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Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation mTOR: An attractive therapeutic target for osteosarcoma?Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomopathies: mechanisms of disease.Ribosomal proteins: functions beyond the ribosome Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription.Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.TFIIS.h, a new target of p53, regulates transcription efficiency of pro-apoptotic bax gene Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53 Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator Antitumor effect of miR-197 targeting in p53 wild-type lung cancer.Does not hUTP14a promoter form a regulation feedback loop with P53?New insights into p53 functions through its target microRNAs.Targeting p53-MDM2-MDMX loop for cancer therapy.Battle against cancer: an everlasting saga of p53.The molecular pathogenesis of the myelodysplastic syndromes.Role of the nucleus in apoptosis: signaling and execution.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Ribosomal proteins L11 and L5 activate TAp73 by overcoming MDM2 inhibition.Negative auto-regulators trap p53 in their web.Reviving the guardian of the genome: Small molecule activators of p53.RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription.Involvement of RPL11 in the enhancement of P53 stability by a podophyllum derivative, a topoisomerase II inhibitor.GRWD1, a new player among oncogenesis-related ribosomal/nucleolar proteins.Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes.Influenza A viruses alter the stability and antiviral contribution of host E3-ubiquitin ligase Mdm2 during the time-course of infection.SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer.The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications.

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P2860

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

http://www.wikidata.org/entity/Q38059701

description

article científic

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article scientifique

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articol științific

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artigo científico

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artigo científico

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artikel ilmiah

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artikull shkencor

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artículo científico

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name

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

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type

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Scission of the p53-MDM2 Loop by Ribosomal Proteins.

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prefLabel

Scission of the p53-MDM2 Loop by Ribosomal Proteins.

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Scission of the p53-MDM2 Loop by Ribosomal Proteins.

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Hua Lu

http://www.w3.org/2001/XMLSchema#string

Jun-Ming Liao

http://www.w3.org/2001/XMLSchema#string

Wen-Juan Liao

http://www.w3.org/2001/XMLSchema#string

Xiang Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Regulation of nucleolar signalling to p53 through NEDDylation of L11

Acetylation is indispensable for p53 activation

Ribosomal proteins are targets for the NEDD8 pathway

Inhibition of c-Myc activity by ribosomal protein L11

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298-310

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10.1177/1947601912455200

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3-4

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3

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2012-03-01T00:00:00Z

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23150763

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