Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy. - Wikidata - awgldk - TriplyDB

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

http://www.wikidata.org/entity/Q38059739

about

Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 p53 Family and Cellular Stress Responses in Cancer.Suberoyl bis-hydroxamic acid enhances cytotoxicity induced by proteasome inhibitors in breast cancer cells.Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms.Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53.Chemical and semisynthetic approaches to study and target deubiquitinases.Usp5 functions as an oncogene for stimulating tumorigenesis in hepatocellular carcinoma.Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway.Ubiquitin conjugating enzyme E2 L3 promoted tumor growth of NSCLC through accelerating p27kip1 ubiquitination and degradation.Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity.Proteasome inhibitor MG132 induces thyroid cancer cell apoptosis by modulating the activity of transcription factor FOXO3a.

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P2860

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

http://www.wikidata.org/entity/Q38059739

description

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artikel ilmiah

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Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

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type

label

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

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prefLabel

Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

@en

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1381612811319180009

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Current Pharmaceutical Design

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Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy.

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Mu-Shui Dai

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Tiffany Devine

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P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

GADD45 induction of a G2/M cell cycle checkpoint

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

PUMA, a novel proapoptotic gene, is induced by p53

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX

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3248-3262

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scholarly article

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10.2174/1381612811319180009

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2013-01-01T00:00:00Z

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ubiquitin-proteasome system

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