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FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated SchwannomasActivation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancerPAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesisSmall molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)miR-137 inhibits proliferation of melanoma cells by targeting PAK2Protein kinase CK2 phosphorylates and activates p21-activated kinase 1Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activityPAK signalling during the development and progression of cancerTranscriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesisA computational strategy to select optimized protein targets for drug development toward the control of cancer diseasesGastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanismsMolecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancersProapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cellsIdentification of novel gene targets and functions of p21-activated kinase 1 during DNA damage by gene expression profilingPrognostic importance and therapeutic implications of PAK1, a drugable protein kinase, in gastroesophageal junction adenocarcinoma.Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven LeukemogenesisOptimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 InhibitorERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion.FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine.Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells.PAK4 confers the malignance of cervical cancers and contributes to the cisplatin-resistance in cervical cancer cells via PI3K/AKT pathway.PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis ComplexThe PAKs come of age: Celebrating 18 years of discovery.Overexpression of PAK-1 is an independent predictor of disease recurrence in colorectal carcinomaMinireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and MetastasisRoles of rho GTPases in intracellular transport and cellular transformation.The p21-activated kinase, PAK2, is important in the activation of numerous pancreatic acinar cell signaling cascades and in the onset of early pancreatitis eventsPAK2 promotes migration and proliferation of salivary gland adenoid cystic carcinomaPTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.P21 activated kinases: structure, regulation, and functions.An oncogenic kinase: putting PAK5 forward.Remarkable reductions of PAKs in the brain tissues of scrapie-infected rodent possibly linked closely with neuron loss.The molecular mechanisms and therapeutic potential of microRNA-7 in cancer.Targeting PAK1.Targeting group I p21-activated kinases to control malignant peripheral nerve sheath tumor growth and metastasis.Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer CellsFunctional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.Clinicopathological and cellular signature of PAK1 in human bladder cancer.In vivo quantitative phosphoproteomic profiling identifies novel regulators of castration-resistant prostate cancer growth.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
PAK signaling in cancer.
@en
type
label
PAK signaling in cancer.
@en
prefLabel
PAK signaling in cancer.
@en
P2860
P356
P1433
P1476
PAK signaling in cancer.
@en
P2093
Diana Zi Ye
Jeffrey Field
P2860
P304
P356
10.4161/CL.21882
P577
2012-04-01T00:00:00Z