The synthesis of Bcr-Abl inhibiting anticancer pharmaceutical agents imatinib, nilotinib and dasatinib.

Item

http://www.wikidata.org/entity/Q38068109

description

article científic

@ca

article scientifique

@fr

articol științific

@ro

articolo scientifico

@it

artigo científico

@gl

artigo científico

@pt

artigo científico

@pt-br

artikel ilmiah

@id

artikull shkencor

@sq

artículo científico

@es

name

The synthesis of Bcr-Abl inhib ...... inib, nilotinib and dasatinib.

@en

type

Item

label

The synthesis of Bcr-Abl inhib ...... inib, nilotinib and dasatinib.

@en

prefLabel

The synthesis of Bcr-Abl inhib ...... inib, nilotinib and dasatinib.

@en

P1476

The synthesis of Bcr-Abl inhib ...... inib, nilotinib and dasatinib.

@en

P2093

Mark D Hopkin

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis for the autoinhibition of c-Abl tyrosine kinase

The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

Overriding imatinib resistance with a novel ABL kinase inhibitor

Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec).

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance.

Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase includ

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1.

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug.

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

Completely N1-selective palladium-catalyzed arylation of unsymmetric imidazoles: application to the synthesis of nilotinib

P304

1766-1800

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

review article

P356

10.1039/C2OB27003J

http://www.w3.org/2001/XMLSchema#string

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Ian R. Baxendale

Benjamin J. Deadman

Steven V. Ley

P577

2012-12-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23247657

http://www.w3.org/2001/XMLSchema#string