Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
about
Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesisInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingp53 and mitochondrial function in neurons.Ribosome-omics of the human ribosome.Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor bodyNucleolar stress with and without p53.High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.AS1411-Induced Growth Inhibition of Glioma Cells by Up-Regulation of p53 and Down-Regulation of Bcl-2 and Akt1 via Nucleolin.SUMO regulates p21Cip1 intracellular distribution and with p21Cip1 facilitates multiprotein complex formation in the nucleolus upon DNA damageRegenerative repair of Pifithrin-α in cerebral ischemia via VEGF dependent manner.Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humansAmino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcriptionThe Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Acrolein preferentially damages nucleolus eliciting ribosomal stress and apoptosis in human cancer cells.Mitochondrial dynamics regulating chemoresistance in gynecological cancers.The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program.PRL‑3 increases the aggressive phenotype of prostate cancer cells in vitro and its expression correlates with high-grade prostate tumors in patients.Diverse Regulators of Human Ribosome Biogenesis Discovered by Changes in Nucleolar Number.Nucleolar stress enhances lytic reactivation of the Kaposi's sarcoma-associated herpesvirus.Nucleolus: Structure and FunctionNucleolar stress: is there a reverse version?Estradiol Prevents High Glucose-Induced β-cell Apoptosis by Decreased BTG2 Expression
P2860
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P2860
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artículo científico
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name
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
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type
label
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
@en
prefLabel
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
@en
P2860
P1476
Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy
@en
P2093
Carlos P Rubbi
Mark T Boyd
P2860
P2888
P304
P356
10.1007/S00018-013-1361-X
P577
2013-05-18T00:00:00Z