Decoding and unlocking the BCL-2 dependency of cancer cells.
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The biology behind B-cell lymphoma 2 as a target in chronic lymphocytic leukemiaTCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xLEarly downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB)MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.Revisiting the hallmarks of cancer.Merkel cell carcinoma dependence on bcl-2 family members for survival.Pharmacokinetics and efficacy of the spleen tyrosine kinase inhibitor r406 after ocular delivery for retinoblastoma.Gossypol induces apoptosis in multiple myeloma cells by inhibition of interleukin-6 signaling and Bcl-2/Mcl-1 pathway.Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancerChemosensitization of solid tumors by inhibition of Bcl-xL expression using DNAzyme.Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation.Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.Bcl-2 family proteins in breast development and cancer: could Mcl-1 targeting overcome therapeutic resistance?MCL-1, BCL-XL and MITF Are Diversely Employed in Adaptive Response of Melanoma Cells to Changes in Microenvironment.Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).Inhibition of Mcl-1 with the pan-Bcl-2 family inhibitor (-)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1Rapamycin rescues ABT-737 efficacy in small cell lung cancerPharmacological inhibition of caspase-8 limits lung tumour outgrowth.YM155 potently triggers cell death in breast cancer cells through an autophagy-NF-kB networkStructure-Function Analysis of the Mcl-1 Protein Identifies a Novel Senescence-regulating Domain.Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid FibroblastsBcl-xL controls a switch between cell death modes during mitotic arrestCyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimeticsThe relevance of molecular biomarkers in cervical cancer patients treated with radiotherapy.A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer.miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation.A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.Mitochondria: gatekeepers of response to chemotherapyProtect and serve: Bcl-2 proteins as guardians and rulers of cancer cell survival.Arginine methylation of USP9X promotes its interaction with TDRD3 and its anti-apoptotic activities in breast cancer cells.The apoptotic mechanisms of MT-6, a mitotic arrest inducer, in human ovarian cancer cells.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.Kinase-inhibitor-insensitive cancer stem cells in chronic myeloid leukemia.Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment.New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis.Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models.PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
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Decoding and unlocking the BCL-2 dependency of cancer cells.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Decoding and unlocking the BCL-2 dependency of cancer cells.
@en
type
label
Decoding and unlocking the BCL-2 dependency of cancer cells.
@en
prefLabel
Decoding and unlocking the BCL-2 dependency of cancer cells.
@en
P2093
P356
P1476
Decoding and unlocking the BCL-2 dependency of cancer cells.
@en
P2093
Fabien Gautier
Mario Campone
Olivier Geneste
Philippe Juin
Stéphane Depil
P2888
P304
P356
10.1038/NRC3538
P407
P577
2013-06-20T00:00:00Z
P6179
1049302343