Glioblastoma: from molecular pathology to targeted treatment.
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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastomaDevelopment of targeted therapies in treatment of glioblastomaThe TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeuticsMolecular characterizations of glioblastoma, targeted therapy, and clinical results to dateHeterogeneity of epidermal growth factor receptor signalling networks in glioblastomaContemporary murine models in preclinical astrocytoma drug developmentMechanical confinement triggers glioma linear migration dependent on formin FHOD3.Advancing the understanding of autism disease mechanisms through geneticsSingle-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastomaA combinatorial radiographic phenotype may stratify patient survival and be associated with invasion and proliferation characteristics in glioblastomaMetabotropic glutamate receptors as a new therapeutic target for malignant gliomasSpecific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.Nanoparticulate Tetrac Inhibits Growth and Vascularity of Glioblastoma Xenografts.An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain CancersmTORC2 in the center of cancer metabolic reprogrammingGreater than the sum of its parts: single-nucleus sequencing identifies convergent evolution of independent EGFR mutants in GBM.Report of the Jumpstarting Brain Tumor Drug Development Coalition and FDA clinical trials neuroimaging endpoint workshop (January 30, 2014, Bethesda MD).Phase II study of PX-866 in recurrent glioblastoma.Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma.Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma.Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance.Glioblastoma extracellular vesicles: reservoirs of potential biomarkers.Serum microRNA-128 as a biomarker for diagnosis of glioma.Metformin inhibits growth of human glioblastoma cells and enhances therapeutic responseA Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy.Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.Proteomic profiling of patient-derived glioblastoma xenografts identifies a subset with activated EGFR: implications for drug development.Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.Tyrosine receptor kinase B is a drug target in astrocytomas.Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.EGFR Mutation Promotes Glioblastoma through Epigenome and Transcription Factor Network Remodeling.Glioblastomas require integrin αvβ3/PAK4 signaling to escape senescence.mTORC2 and Metabolic Reprogramming in GBM: at the Interface of Genetics and Environment.Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.Genetically engineered rat gliomas: PDGF-driven tumor initiation and progression in tv-a transgenic rats recreate key features of human brain cancer.Comprehensive portrait of recurrent glioblastoma multiforme in molecular and clinical characteristics.Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo.Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivoLoss of endothelial programmed cell death 10 activates glioblastoma cells and promotes tumor growth.
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Glioblastoma: from molecular pathology to targeted treatment.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
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name
Glioblastoma: from molecular pathology to targeted treatment.
@en
type
label
Glioblastoma: from molecular pathology to targeted treatment.
@en
prefLabel
Glioblastoma: from molecular pathology to targeted treatment.
@en
P2093
P1476
Glioblastoma: from molecular pathology to targeted treatment.
@en
P2093
Paul S Mischel
Timothy F Cloughesy
Webster K Cavenee
P356
10.1146/ANNUREV-PATHOL-011110-130324
P577
2013-08-05T00:00:00Z