RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
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Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapyRegulation of signaling events involved in the pathophysiology of neovascular AMDCancer Cell Fusion: Mechanisms Slowly UnravelR-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and MetastasisNovel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPasesTherapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancerGamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells.Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian CancerMicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603.Rap1 GTPase Inhibits Tumor Necrosis Factor-α-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-κB-Dependent Activation of Rac1.ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion.Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.Endothelial Rac1 is essential for hematogenous metastasis to the lungA Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.RAC1 P29S regulates PD-L1 expression in melanoma.Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinomaGlutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker.A20 inhibits the motility of HCC cells induced by TNF-αLeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells.Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis.Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN lossTiam1/Rac1 complex controls Il17a transcription and autoimmunity.Rac1 overexpression is correlated with epithelial mesenchymal transition and predicts poor prognosis in non-small cell lung cancer.Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.Rab23's genetic structure, function and related diseases: a review.Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways.Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis.A prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancer.TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral CancerProteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin.
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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
@en
type
label
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
@en
prefLabel
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
@en
P2093
P2860
P1476
RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.
@en
P2093
Hemant K Bid
Parmeet K Manchanda
Peter J Houghton
Ryan D Roberts
P2860
P304
P356
10.1158/1535-7163.MCT-13-0164
P577
2013-09-26T00:00:00Z