RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis. - Wikidata - awgldk - TriplyDB

RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

http://www.wikidata.org/entity/Q38145091

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Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy Regulation of signaling events involved in the pathophysiology of neovascular AMD Cancer Cell Fusion: Mechanisms Slowly Unravel R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Gamma-Secretase Inhibitor IX (GSI) Impairs Concomitant Activation of Notch and Wnt-Beta-Catenin Pathways in CD44+ Gastric Cancer Stem Cells.Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation.Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog.Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer MicroRNA expression profiling predicts clinical outcome of carboplatin/paclitaxel-based therapy in metastatic melanoma treated on the ECOG-ACRIN trial E2603.Rap1 GTPase Inhibits Tumor Necrosis Factor-α-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-κB-Dependent Activation of Rac1.ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion.Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1.Endothelial Rac1 is essential for hematogenous metastasis to the lung A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.RAC1 P29S regulates PD-L1 expression in melanoma.Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.Dendritic spine remodeling following early and late Rac1 inhibition after spinal cord injury: evidence for a pain biomarker.A20 inhibits the motility of HCC cells induced by TNF-α LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer Cells.Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis.Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.Rac1 overexpression is correlated with epithelial mesenchymal transition and predicts poor prognosis in non-small cell lung cancer.Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.DOCK2 interacts with FLT3 and modulates the survival of FLT3-expressing leukemia cells.Rab23's genetic structure, function and related diseases: a review.Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways.Inhibitory Effects of Dopamine Receptor D1 Agonist on Mammary Tumor and Bone Metastasis.A prognostic mutation panel for predicting cancer recurrence in stages II and III colorectal cancer.TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: implications for CTCL.Biomaterial-enabled delivery of SDF-1α at the ventral side of breast cancer cells reveals a crosstalk between cell receptors to promote the invasive phenotype.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.In Silico Approach for SAR Analysis of the Predicted Model of DEPDC1B: A Novel Target for Oral Cancer Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin.

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

http://www.wikidata.org/entity/Q38145091

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

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1535-7163.MCT-13-0164

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Molecular Cancer Therapeutics

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RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.

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Hemant K Bid

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Parmeet K Manchanda

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Peter J Houghton

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Ryan D Roberts

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P2860

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

Rac and Rho GTPases in cancer cell motility control

Hallmarks of Cancer: The Next Generation

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

Modes of resistance to anti-angiogenic therapy

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

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1925-1934

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10.1158/1535-7163.MCT-13-0164

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10

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12

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2013-09-26T00:00:00Z

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3823055

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