Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
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Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their CrosstalksRadioresistance of Brain TumorsHedgehog signaling: modulation of cancer properies and tumor mircroenvironmentTargeting the Hedgehog Pathway in Pediatric MedulloblastomaHedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic SignalingThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseIns and outs of GPCR signaling in primary ciliaHedgehog Signaling in Malignant Pleural MesotheliomaCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapySmoothened variants explain the majority of drug resistance in basal cell carcinomaCilium assembly and disassemblyUnraveling the Anticancer Effect of Curcumin and ResveratrolSurvival regulation of leukemia stem cellsCyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cellsHedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clustersA Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia ElongationHedgehog pathway maintains cell survival under stress conditions, and drives drug resistance in lung adenocarcinomaCan oncology recapitulate paleontology? Lessons from species extinctionsThe role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcomaDesign, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer.Disruption of SHH signaling cascade by SBE attenuates lung cancer progression and sensitizes DDP treatmentPotential smoothened inhibitor from traditional Chinese medicine against the disease of diabetes, obesity, and cancerSmoothened gene alterations in keratocystic odontogenic tumors.Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalDisrupting the balance between tumor epithelia and stroma is a possible therapeutic approach for pancreatic cancer.CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide.Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis.Repurposing the antihelmintic mebendazole as a hedgehog inhibitor.Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.Variant allele frequency enrichment analysis in vitro reveals sonic hedgehog pathway to impede sustained temozolomide response in GBMGlobal profiling of protein lipidation using chemical proteomic technologiesVismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste budsContributions of Costal 2-Fused interactions to Hedgehog signaling in DrosophilaThe prognostic value of stroma in pancreatic cancer in patients receiving adjuvant therapySurvivin as a therapeutic target in Sonic hedgehog-driven medulloblastomaEndocannabinoids are conserved inhibitors of the Hedgehog pathway.Genome-wide microarray expression and genomic alterations by array-CGH analysis in neuroblastoma stem-like cells.MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.De novo branching cascades for structural and functional diversity in small molecules.
P2860
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P2860
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
@en
type
label
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
@en
prefLabel
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
@en
P2093
P356
P1433
P1476
Unraveling the therapeutic potential of the Hedgehog pathway in cancer.
@en
P2093
Dereck Amakye
Marion Dorsch
Zainab Jagani
P2888
P304
P356
10.1038/NM.3389
P407
P577
2013-11-07T00:00:00Z