Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.
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Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary ImmunodeficienciesRoles and regulations of the ETS transcription factor ELF4/MEFTargeting the tyrosine kinase signalling pathways for treatment of immune-mediated glomerulonephritis: from bench to bedside and beyond.Safety, pharmacokinetics, and pharmacodynamics of BMS-986142, a novel reversible BTK inhibitor, in healthy participantsSplice-correction strategies for treatment of X-linked agammaglobulinemia.Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in MiceHigh-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia.The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacementOral administration of Bruton's tyrosine kinase inhibitors impairs GPVI-mediated platelet function.A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers.Ibrutinib (ImbruvicaTM) potently inhibits ErbB receptor phosphorylation and cell viability of ErbB2-positive breast cancer cells.The Btk-dependent PIP5K1γ lipid kinase activation by Fas counteracts FasL-induced cell death.Delayed diagnosis in X-linked agammaglobulinemia and its relationship to the occurrence of mutations in BTK non-kinase domains.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Increased expression of Bruton's tyrosine kinase in peripheral blood is associated with lupus nephritis.Inhibiting Bruton's Tyrosine Kinase Rescues Mice from Lethal Influenza Induced Acute Lung Injury.
P2860
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P2860
Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.
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2013 nî lūn-bûn
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Bruton's tyrosine kinase--an i ...... e in the innate immune system.
@en
type
label
Bruton's tyrosine kinase--an i ...... e in the innate immune system.
@en
prefLabel
Bruton's tyrosine kinase--an i ...... e in the innate immune system.
@en
P2093
P2860
P356
P1476
Bruton's tyrosine kinase--an i ...... e in the innate immune system.
@en
P2093
Alexander Vargas-Hernández
Francisco Espinosa-Rosales
Gabriela López-Herrera
Juan Carlos Rodríguez-Alba
Laura Berrón-Ruiz
Maria Edith González-Serrano
P2860
P304
P356
10.1189/JLB.0513307
P577
2013-11-18T00:00:00Z