Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
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Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative diseaseInsights into Mechanisms of Chronic NeurodegenerationUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesRelevance of chronic stress and the two faces of microglia in Parkinson's diseasePrion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage responseSynthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseasesNeurodegenerative diseases: expanding the prion conceptPassive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy modelsMembrane remodeling and mechanics: Experiments and simulations of α-SynucleinSpreading of pathology in neurodegenerative diseases: a focus on human studiesAlpha-synuclein spreading in Parkinson's diseaseEngineering enhanced protein disaggregases for neurodegenerative diseaseThe use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and researchMitochondrial dysfunction associated with glucocerebrosidase deficiencyProtein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitusBiochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's diseaseThe Dynamics and Turnover of Tau Aggregates in Cultured Cells: INSIGHTS INTO THERAPIES FOR TAUOPATHIES.Propagation of pathology through brain networks in neurodegenerative diseases: from molecules to clinical phenotypes.Glial contributions to neurodegeneration in tauopathies.Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortexSingle cell imaging and quantification of TDP-43 and α-synuclein intercellular propagation.Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients.Stability of Iowa mutant and wild type Aβ-peptide aggregatesModels of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brainsAnti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism.Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injuryTDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cordΑ-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Amyloid polymorphism: structural basis and neurobiological relevance.Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation.Cell-based therapies for Parkinson disease—past insights and future potential.Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain.Progression of Seed-Induced Aβ Deposition within the Limbic Connectome
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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
description
article científic
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article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
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type
label
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
@en
prefLabel
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
@en
P2860
P356
P1433
P1476
Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases.
@en
P2093
Jing L Guo
Virginia M Y Lee
P2860
P2888
P304
P356
10.1038/NM.3457
P407
P577
2014-02-01T00:00:00Z