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Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literatureMechanisms Behind the Resistance to Trastuzumab in HER2-Amplified Breast Cancer and Strategies to Overcome ItRegulation of ERBB3/HER3 signaling in cancerIntermolecular biparatopic trapping of ErbB2 prevents compensatory activation of PI3K/AKT via RAS-p110 crosstalk.Gene expression markers of efficacy and resistance to cetuximab treatment in metastatic colorectal cancer: results from CALGB 80203 (Alliance)Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.Mesenchymal stem cell-conditioned medium promotes MDA-MB-231 cell migration and inhibits A549 cell migration by regulating insulin receptor and human epidermal growth factor receptor 3 phosphorylation.Integrated data analysis reveals potential drivers and pathways disrupted by DNA methylation in papillary thyroid carcinomas.High expression of PLA2G16 is associated with a better prognosis in HER2-positive breast cancer.Picking the Right Patient for Human Epidermal Growth Factor Receptor 3-Targeted Therapy in Platinum-Resistant Ovarian CancerPhase 1 Evaluation of [(64)Cu]DOTA-Patritumab to Assess Dosimetry, Apparent Receptor Occupancy, and Safety in Subjects with Advanced Solid Tumors.Suppression of feedback loops mediated by PI3K/mTOR induces multiple overactivation of compensatory pathways: an unintended consequence leading to drug resistance.HER-3 targeting alters the dimerization pattern of ErbB protein family members in breast carcinomas.Examination of HER3 targeting in cancer using monoclonal antibodiesThe anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cellsPerhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.A high speed multifocal multiphoton fluorescence lifetime imaging microscope for live-cell FRET imagingComparative Gene Expression Analyses Identify Luminal and Basal Subtypes of Canine Invasive Urothelial Carcinoma That Mimic Patterns in Human Invasive Bladder Cancer.The Therapeutic Challenge of Targeting HER2 in Endometrial CancerAffibody-mediated PET imaging of HER3 expression in malignant tumours.Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cellsHypoxia/lncRNA-AK123072/EGFR pathway induced metastasis and invasion in gastric cancer.ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3.Characterization of a P-Rex1 gene signature in breast cancer cellsFGFR3-TACC3 fusion proteins act as naturally occurring drivers of tumor resistance by functionally substituting for EGFR/ERK signaling.Adaptive resistance to RAF inhibitors in melanoma.Antibodies directed against receptor tyrosine kinases: current and future strategies to fight cancer.HER3/ErbB3, an emerging cancer therapeutic target.The impact of structural biology in medicine illustrated with four case studies.MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice.HER3 as a Therapeutic Target in Cancer.High expression of EGFR predicts poor survival in patients with resected T3 stage gastric adenocarcinoma and promotes cancer cell survivalTumor suppressor microRNA-31 inhibits gastric carcinogenesis by targeting Smad4 and SGPP2.Effects of silibinin on growth and invasive properties of human ovarian carcinoma cells through suppression of heregulin/HER3 pathway.HER2 and EGFR amplification and expression in urothelial carcinoma occurs in distinct biological and molecular contexts.hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.Deciphering and Targeting Oncogenic Mutations and Pathways in Breast Cancer.Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapyPertuzumab and trastuzumab: the rationale way to synergy.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Molecular pathways: HER3 targeted therapy
@en
type
label
Molecular pathways: HER3 targeted therapy
@en
prefLabel
Molecular pathways: HER3 targeted therapy
@en
P2860
P1476
Molecular pathways: HER3 targeted therapy
@en
P2093
Kinisha Gala
Sarat Chandarlapaty
P2860
P304
P356
10.1158/1078-0432.CCR-13-1549
P407
P577
2014-02-11T00:00:00Z