PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells - Wikidata - awgldk - TriplyDB

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

http://www.wikidata.org/entity/Q24540039

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The emerging importance of group II PAKs The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis Huntingtin promotes cell survival by preventing Pak2 cleavage Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.Group I and II mammalian PAKs have different modes of activation by Cdc42 PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD Group II p21-activated kinases as therapeutic targets in gastrointestinal cancer Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6 Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?Signaling, Regulation, and Specificity of the Type II p21-activated Kinases Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain PAK4 kinase is essential for embryonic viability and for proper neuronal development Upregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injury PAK thread from amoeba to mammals PAK as a therapeutic target in gastric cancer Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice PAK1 negatively regulates the activity of the Rho exchange factor NET1 Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2 Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration.Expression patterns of protein kinases correlate with gene architecture and evolutionary rates.P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinoma.Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS.Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.A role for p21-activated kinase 7 in the development of gastric cancer.PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell.The overexpression of P21-activated kinase 5 (PAK5) promotes paclitaxel-chemoresistance of epithelial ovarian cancer.P21-activated kinase 7 mediates cisplatin-resistance of esophageal squamous carcinoma cells with Aurora-A overexpression.p21-Activated kinase 5 affects cisplatin-induced apoptosis and proliferation in hepatocellular carcinoma cells.Efficient inhibition of human glioma development by RNA interference-mediated silencing of PAK5 GATA1 induces epithelial-mesenchymal transition in breast cancer cells through PAK5 oncogenic signaling.CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186.Emerging functions of p21-activated kinases in human cancer cells.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Hydrogels derived from central nervous system extracellular matrix.Gene expression correlates of neurofibrillary tangles in Alzheimer's disease.Targeted disruption of the gene for the PAK5 kinase in mice.p21 activated kinase 5 activates Raf-1 and targets it to mitochondria A tale of two Paks.

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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description

2002 nî lūn-bûn

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2002 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2002年の論文

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name

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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type

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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prefLabel

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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MCB.22.2.567-577.2002

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Molecular and Cellular Biology

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PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells

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Audrey Minden

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Muriel Liberto

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Niharika Nath

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P2860

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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