Assembly line polyketide synthases: mechanistic insights and unsolved problems. - Wikidata - awgldk - TriplyDB

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

http://www.wikidata.org/entity/Q38208037

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Recent Advances in Understanding and Engineering Polyketide Synthesis Architecture of the polyketide synthase module: surprises from electron cryo-microscopy Endless Resistance. Endless Antibiotics?Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase X-ray Scattering Studies of Protein Structural Dynamics.Probing the phosphopantetheine arm conformations of acyl carrier proteins using vibrational spectroscopy.Fungal polyketide engineering comes of age.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.Structural elements of an NRPS cyclization domain and its intermodule docking domain.The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.Explorations of fungal biosynthesis of reduced polyketides - a personal viewpoint.Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects.Mining Bacterial Genomes for Secondary Metabolite Gene Clusters.Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins.Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds.Salinipyrone and Pacificanone Are Biosynthetic By-products of the Rosamicin Polyketide Synthase.Twofold polyketide branching by a stereoselective enzymatic Michael addition.Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase.An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli.Engineering modular polyketide synthases for production of biofuels and industrial chemicals.Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay.Metabolism: 'channeling' Hans Krebs.Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory.Insights into the programmed ketoreduction of partially reducing polyketide synthases: stereo- and substrate-specificity of the ketoreductase domain

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P2860

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

http://www.wikidata.org/entity/Q38208037

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Assembly line polyketide synthases: mechanistic insights and unsolved problems.

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type

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Assembly line polyketide synthases: mechanistic insights and unsolved problems.

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Assembly line polyketide synthases: mechanistic insights and unsolved problems.

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Assembly line polyketide synthases: mechanistic insights and unsolved problems.

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Chaitan Khosla

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Christopher T Walsh

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Daniel Herschlag

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David E Cane

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P2860

The structure of docking domains in modular polyketide synthases

A tylosin ketoreductase reveals how chirality is determined in polyketides

Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase

Crystal structure of the termination module of a nonribosomal peptide synthetase

The crystal structure of a mammalian fatty acid synthase

Crystal Structure of the Erythromycin Polyketide Synthase Dehydratase

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer

Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent Stereochemistry

Crystal structures of the first condensation domain of CDA synthetase suggest conformational changes during the synthetic cycle of nonribosomal peptide synthetases.

Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer

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10.1021/BI500290T

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18

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2014-05-01T00:00:00Z

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262000017

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24779441

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