Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer
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Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthasesStructure of the Bifunctional Acyltransferase/Decarboxylase LnmK from the Leinamycin Biosynthetic Pathway Revealing Novel Activity for a Double-Hot-Dog FoldAn antibiotic factory caught in actionProbing the compatibility of type II ketosynthase-carrier protein partners.Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.The enzymology of combinatorial biosynthesis.The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters.Biosynthesis of aromatic polyketides in bacteria.Lomaiviticin biosynthesis employs a new strategy for starter unit generation.Assembly line polyketide synthases: mechanistic insights and unsolved problems.Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase.Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.Antibiotic discovery throughout the Small World Initiative: A molecular strategy to identify biosynthetic gene clusters involved in antagonistic activity.In vivo and in vitro analysis of the hedamycin polyketide synthase.Site-specific mutagenesis and domain substitutions in the loading module of the nystatin polyketide synthase, and their effects on nystatin biosynthesis in Streptomyces noursei.Tandemly duplicated acyl carrier proteins, which increase polyketide antibiotic production, can apparently function either in parallel or in series.Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase.Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.Reconstitution of a Type II Polyketide Synthase Catalyzing Polyene Formation.Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.
P2860
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P2860
Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer
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2000年の論文
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Mechanistic analysis of a type ...... hain length factor heterodimer
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Mechanistic analysis of a type ...... hain length factor heterodimer
@en
Mechanistic analysis of a type ...... hain length factor heterodimer
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Mechanistic analysis of a type ...... hain length factor heterodimer
@ast
Mechanistic analysis of a type ...... hain length factor heterodimer
@en
Mechanistic analysis of a type ...... hain length factor heterodimer
@nl
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Mechanistic analysis of a type ...... hain length factor heterodimer
@ast
Mechanistic analysis of a type ...... hain length factor heterodimer
@en
Mechanistic analysis of a type ...... hain length factor heterodimer
@nl
P356
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Mechanistic analysis of a type ...... hain length factor heterodimer
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P2093
P304
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10.1021/BI992121L
P407
P577
2000-02-29T00:00:00Z