In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery. - Wikidata - awgldk - TriplyDB

In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

http://www.wikidata.org/entity/Q38214334

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How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusion Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat.Hepatic drug transporters: the journey so far.Transporter assays as useful in vitro tools in drug discovery and development.Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifape The apparent permeabilities of Caco-2 cells to marketed drugs: magnitude, and independence from both biophysical properties and endogenite similarities.The transport mechanism of monocarboxylate transporter on spinosin in Caco-2 cells Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response.

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In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery.

http://www.wikidata.org/entity/Q38214334

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In vitro and in vivo approache ...... disposition in drug discovery.

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In vitro and in vivo approache ...... disposition in drug discovery.

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Expert Opinion on Drug Discovery

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In vitro and in vivo approache ...... disposition in drug discovery.

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Bo Feng

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Chester Costales

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Larry Tremaine

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Manthena V Varma

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Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

Membrane transporters in drug development

SLCO1B1 variants and statin-induced myopathy--a genomewide study

Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.

Construction of a functional transporter analysis system using MDR1 knockdown Caco-2 cells.

Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.

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