Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).
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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine.Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.Hepatic drug transporters: the journey so far.BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs.The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.BDDCS, the Rule of 5 and drugability.Evaluation and Quantitative Prediction of Renal Transporter-Mediated Drug-Drug Interactions.Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance.Drug Disposition Classification Systems in Discovery and Development: A Comparative Review of the BDDCS, ECCS and ECCCS Concepts.Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.Transport vs. Metabolism: What Determines the Pharmacokinetics and Pharmacodynamics of Drugs? Insights From the Extended Clearance Model.Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib.A unified strategy in selection of the best allometric scaling methods to predict human clearance based on drug disposition pathway.Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions.Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.Commentary on "The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio".Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.Extended Clearance Classification System (ECCS) informed approach for evaluating investigational drugs as substrates of drug transporters.Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds
P2860
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P2860
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Predicting Clearance Mechanism ...... Classification System (ECCS).
@en
type
label
Predicting Clearance Mechanism ...... Classification System (ECCS).
@en
prefLabel
Predicting Clearance Mechanism ...... Classification System (ECCS).
@en
P2093
P2860
P1476
Predicting Clearance Mechanism ...... Classification System (ECCS).
@en
P2093
Ayman F El-Kattan
Charlotte Allerton
Manthena V Varma
Stefanus J Steyn
P2860
P304
P356
10.1007/S11095-015-1749-4
P577
2015-07-09T00:00:00Z