Is it time to test biguanide metformin in the treatment of melanoma? - Wikidata - awgldk - TriplyDB

Is it time to test biguanide metformin in the treatment of melanoma?

Is it time to test biguanide metformin in the treatment of melanoma?

http://www.wikidata.org/entity/Q38215034

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Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.Combined regimen of photodynamic therapy mediated by Gallium phthalocyanine chloride and Metformin enhances anti-melanoma efficacy Metformin upregulates E-cadherin and inhibits B16F10 cell motility, invasion and migration.Combinational strategies of metformin and chemotherapy in cancers.Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications.The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells.Efficacy of metformin in combination with immune checkpoint inhibitors (anti-PD-1/anti-CTLA-4) in metastatic malignant melanoma.Effects of metformin treatment on radiotherapy efficacy in patients with cancer and diabetes: a systematic review and meta-analysis Metformin: Focus on Melanoma

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Is it time to test biguanide metformin in the treatment of melanoma?

http://www.wikidata.org/entity/Q38215034

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Is it time to test biguanide metformin in the treatment of melanoma?

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Is it time to test biguanide metformin in the treatment of melanoma?

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Is it time to test biguanide metformin in the treatment of melanoma?

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Pigment Cell & Melanoma Research

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Is it time to test biguanide metformin in the treatment of melanoma?

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Michael Cerezo

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Stéphane Rocchi

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Tijana Tomic

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P2860

Role of AMP-activated protein kinase in mechanism of metformin action

Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

AMPK phosphorylation of raptor mediates a metabolic checkpoint

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

On the Origin of Cancer Cells

Rag proteins regulate amino-acid-induced mTORC1 signalling.

A protein conjugation system essential for autophagy.

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8-20

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scholarly article

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10.1111/PCMR.12267

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1

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28

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Robert Ballotti

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2014-06-26T00:00:00Z

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262643822

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24862830

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