Biased ligands at G-protein-coupled receptors: promise and progress.
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The search for novel analgesics: targets and mechanismsG Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRsAnalyzing the roles of multi-functional proteins in cells: The case of arrestins and GRKsPTH receptor-1 signalling-mechanistic insights and therapeutic prospectsStudying GPCR/cAMP pharmacology from the perspective of cellular structure(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signalingStructure and function of serotonin G protein-coupled receptors.Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors.Minireview: Spatial Programming of G Protein-Coupled Receptor Activity: Decoding Signaling in Health and DiseaseCB2 Cannabinoid receptors as a therapeutic target-what does the future hold?Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Discovery of GPCR ligands for probing signal transduction pathways.Opioid receptor desensitization: mechanisms and its link to toleranceInvolvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort.Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism.Investigation of the fate of type I angiotensin receptor after biased activationQuantifying conformational changes in GPCRs: glimpse of a common functional mechanism.From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily.Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2.Dysregulated Inflammatory Signaling upon Charcot-Marie-Tooth Type 1C Mutation of SIMPLE Protein.Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18).Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.Opioid receptors: Structural and mechanistic insights into pharmacology and signaling.Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties.Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulationThe role of kinetic context in apparent biased agonism at GPCRs.G Protein-coupled Receptor Biased Agonism.Bombesin-like receptor 3 regulates blood pressure and heart rate via a central sympathetic mechanismNew paradigms in GPCR drug discovery.A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional BiasArrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.Characterization of Structurally Novel G Protein Biased CB1 Agonists: Implications for Drug Development.Modification of the Orthosteric PPARγ Covalent Antagonist Scaffold Yields an Improved Dual-Site Allosteric Inhibitor.NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.Biased agonism: An emerging paradigm in GPCR drug discovery.Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.
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P2860
Biased ligands at G-protein-coupled receptors: promise and progress.
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article científic
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article scientifique
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articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Biased ligands at G-protein-coupled receptors: promise and progress.
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type
label
Biased ligands at G-protein-coupled receptors: promise and progress.
@en
prefLabel
Biased ligands at G-protein-coupled receptors: promise and progress.
@en
P2093
P1476
Biased ligands at G-protein-coupled receptors: promise and progress.
@en
P2093
Aimee L Crombie
David G Soergel
Jonathan D Violin
Michael W Lark
P304
P356
10.1016/J.TIPS.2014.04.007
P577
2014-05-28T00:00:00Z