LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
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Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseParkinson's Disease: The Mitochondria-Iron LinkLRRK2 inhibitors and their potential in the treatment of Parkinson's disease: current perspectivesThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseA visual review of the interactome of LRRK2: Using deep-curated molecular interaction data to represent biology.Parkinson-Related LRRK2 Mutation R1628P Enables Cdk5 Phosphorylation of LRRK2 and Upregulates Its Kinase ActivityInterplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective AutophagyLeucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia.LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit functionBeyond traditional pharmacology: new tools and approaches.Counteracting PINK/Parkin Deficiency in the Activation of Mitophagy: A Potential Therapeutic Intervention for Parkinson's Disease.LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.Selective neuronal vulnerability in Parkinson disease.From the baker to the bedside: yeast models of Parkinson's disease.68 and FX2149 Attenuate Mutant LRRK2-R1441C-Induced Neural Transport Impairment.Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation.LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1.Cynefin as Reference Framework to Facilitate Insight and Decision-Making in Complex Contexts of Biomedical Research.Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease.The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease.LRRK2: An Emerging New Molecule in the Enteric Neuronal System That Quantitatively Regulates Neuronal Peptides and IgA in the Gut.Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.lncRNA MALAT1/miR-205-5p axis regulates MPP+-induced cell apoptosis in MN9D cells by directly targeting LRRK2.Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson's disease.In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson's Disease Pathology.
P2860
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P2860
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
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2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
@en
type
label
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
@en
prefLabel
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
@en
P2860
P1476
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis
@en
P2093
A Raquel Esteves
P2860
P304
P356
10.1016/J.EXPNEUROL.2014.05.025
P407
P577
2014-06-04T00:00:00Z