Regulation of TFEB and V-ATPases by mTORC1. - Wikidata - awgldk - TriplyDB

Regulation of TFEB and V-ATPases by mTORC1.

Regulation of TFEB and V-ATPases by mTORC1.

http://www.wikidata.org/entity/Q38256715

about

The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function ZKSCAN3 is a master transcriptional repressor of autophagy The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction State of the science: an update on renal cell carcinoma mTOR signaling in growth control and disease Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects The crucial impact of lysosomes in aging and longevity Sanfilippo syndrome: causes, consequences, and treatments Autophagy and the (Pro)renin Receptor Amino acids and mTORC1: from lysosomes to disease βA3/A1-crystallin: more than a lens protein Lysosomal proteins in cell death and autophagy Advances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ Damage Transcriptional and epigenetic regulation of autophagy in aging Beyond indigestion: emerging roles for lysosome-based signaling in human disease Reprogramming of lysosomal gene expression by interleukin-4 and Stat6 An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.Elucidation of how cancer cells avoid acidosis through comparative transcriptomic data analysis.Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans.Lysosomal adaptation: how the lysosome responds to external cues Novel roles for the MiTF/TFE family of transcription factors in organelle biogenesis, nutrient sensing, and energy homeostasis Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes BAP1 loss defines a new class of renal cell carcinoma.Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes Signals from the lysosome: a control centre for cellular clearance and energy metabolism.Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications.Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.Cobalt protoporphyrin accelerates TFEB activation and lysosome reformation during LPS-induced septic insults in the rat heart Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis.Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.

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Regulation of TFEB and V-ATPases by mTORC1.

http://www.wikidata.org/entity/Q38256715

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

@zh-tw

2011年论文

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2011年论文

@zh

2011年论文

@zh-cn

name

Regulation of TFEB and V-ATPases by mTORC1.

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type

label

Regulation of TFEB and V-ATPases by mTORC1.

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prefLabel

Regulation of TFEB and V-ATPases by mTORC1.

@en

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The EMBO Journal

P1476

Regulation of TFEB and V-ATPases by mTORC1

@en

P2093

David R Corey

http://www.w3.org/2001/XMLSchema#string

Jacob C Schwartz

http://www.w3.org/2001/XMLSchema#string

James Brugarolas

http://www.w3.org/2001/XMLSchema#string

Lihua Zou

http://www.w3.org/2001/XMLSchema#string

Nicholas C Wolff

http://www.w3.org/2001/XMLSchema#string

Silvia Vega-Rubin-de-Celis

http://www.w3.org/2001/XMLSchema#string

Tram Anh T Tran

http://www.w3.org/2001/XMLSchema#string

Xian-Jin Xie

http://www.w3.org/2001/XMLSchema#string

P2860

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

Structural analysis and functional implications of the negative mTORC1 regulator REDD1

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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3242-3258

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scholarly article

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10.1038/EMBOJ.2011.257

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P433

16

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30

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Samuel Peña-Llopis

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2011-07-29T00:00:00Z

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51535792

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21804531

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3160667

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