Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics.
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Oxidized cholesterol as the driving force behind the development of Alzheimer's diseaseMaximally asymmetric transbilayer distribution of anionic lipids alters the structure and interaction with lipids of an amyloidogenic protein dimer bound to the membrane surfaceData supporting beta-amyloid dimer structural transitions and protein-lipid interactions on asymmetric lipid bilayer surfaces using MD simulations on experimentally derived NMR protein structures.Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation.Role of membrane biophysics in Alzheimer's-related cell pathways.Alterations in Lipid Levels of Mitochondrial Membranes Induced by Amyloid-β: A Protective Role of Melatonin.Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.The role of molecular simulations in the development of inhibitors of amyloid β-peptide aggregation for the treatment of Alzheimer's diseaseAtomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer's disease.Ion Channel Formation by Amyloid-β42 Oligomers but Not Amyloid-β40 in Cellular Membranes.Lipid insertion domain unfolding regulates protein orientational transition behavior in a lipid bilayer.Characterization of 3D Voronoi tessellation nearest neighbor lipid shells provides atomistic lipid disruption profile of protein containing lipid membranes.Scaling and alpha-helix regulation of protein relaxation in a lipid bilayer.AβP1-42 incorporation and channel formation in planar lipid membranes: the role of cholesterol and its oxidation products.How transmembrane peptides insert and orientate in biomembranes: a combined experimental and simulation study.
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P2860
Molecular dynamics simulations reveal the protective role of cholesterol in β-amyloid protein-induced membrane disruptions in neuronal membrane mimics.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Molecular dynamics simulations ...... s in neuronal membrane mimics.
@en
type
label
Molecular dynamics simulations ...... s in neuronal membrane mimics.
@en
prefLabel
Molecular dynamics simulations ...... s in neuronal membrane mimics.
@en
P2093
P2860
P356
P1476
Molecular dynamics simulations ...... s in neuronal membrane mimics.
@en
P2093
Andrew Reay
Creighton Buie
Kwan Hon Cheng
Liming Qiu
Mark W Vaughn
P2860
P304
P356
10.1021/JP2012842
P407
P577
2011-07-26T00:00:00Z