Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.
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Methionine tumor starvation by erythrocyte-encapsulated methionine gamma-lyase activity controlled with per os vitamin B6.Recombinant methioninase effectively targets a Ewing's sarcoma in a patient-derived orthotopic xenograft (PDOX) nude-mouse model.Tumor-specific cell-cycle decoy by Salmonella typhimurium A1-R combined with tumor-selective cell-cycle trap by methioninase overcome tumor intrinsic chemoresistance as visualized by FUCCI imaging.The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant DiseaseMultivalent methionine-functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF-7/ADR.Synthesis of a Novel IR-822-Met near-infrared probe for in vivo tumor diagnosis.Timed, sequential administration of paclitaxel improves its cytotoxic effectiveness in a cell culture model.High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug.Structural and mechanistic insights into homocysteine degradation by a mutant of methionine γ-lyase based on substrate-assisted catalysis.Is DNA methylation the new guardian of the genome?The Metal Drives the Chemistry: Dual Functions of Acireductone Dioxygenase.Gene cloning, characterization, and cytotoxic activity of methionine γ-lyase from Clostridium novyi.Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma.Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.Growth of doxorubicin-resistant undifferentiated spindle-cell sarcoma PDOX is arrested by metabolic targeting with recombinant methioninase.The wayward methyl group and the cascade to cancer.Evaluation of METase-pemetrexed-loaded PEG-PLGA nanoparticles modified with anti-CD133-scFV for treatment of gastric carcinoma.Enhancement of the Antitumor Effect of Methotrexate on Colorectal Cancer Cells via Lactate Calcium Salt Targeting Methionine Metabolism.Targeting altered cancer methionine metabolism with recombinant methioninase (rMETase) overcomes partial gemcitabine-resistance and regresses a patient-derived orthotopic xenograft (PDOX) nude mouse model of pancreatic cancer.Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.Structure of methionine γ-lyase from Clostridium sporogenes.Pushing the Limits of Cancer Therapy: The Nutrient Game.Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model.2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation.Breast Cancer and Its Relationship with the Microbiota
P2860
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P2860
Development of recombinant methioninase to target the general cancer-specific metabolic defect of methionine dependence: a 40-year odyssey.
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2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
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2014年學術文章
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name
Development of recombinant met ...... dependence: a 40-year odyssey.
@en
type
label
Development of recombinant met ...... dependence: a 40-year odyssey.
@en
prefLabel
Development of recombinant met ...... dependence: a 40-year odyssey.
@en
P2860
P1476
Development of recombinant met ...... dependence: a 40-year odyssey.
@en
P2093
Robert M Hoffman
P2860
P356
10.1517/14712598.2015.963050
P407
P577
2014-12-02T00:00:00Z