SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
about
Process of Fragment-Based Lead Discovery-A Perspective from NMRDiscovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based DesignTargeting Zinc Finger Domains with Small Molecules: Solution Structure and Binding Studies of the RanBP2-Type Zinc Finger of RBM5Design of Bcl-2 and Bcl-xL Inhibitors with Subnanomolar Binding Affinities Based upon a New ScaffoldSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionDiscovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based designBcL-xL conformational changes upon fragment binding revealed by NMRNMR-based analysis of protein-ligand interactions.Overview of Probing Protein-Ligand Interactions Using NMR.3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.Fragment-based drug discovery using NMR spectroscopyTargeting tumor invasion: the roles of MDA-9/Syntenin.DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.NMR-based approaches for the identification and optimization of inhibitors of protein-protein interactions.New dimension in therapeutic targeting of BCL-2 family proteins.Systematic Targeting of Protein-Protein InteractionsDesigned BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
P2860
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P2860
SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
SAR by interligand nuclear ove ...... ve against Bcl-x(L) and Mcl-1.
@en
type
label
SAR by interligand nuclear ove ...... ve against Bcl-x(L) and Mcl-1.
@en
prefLabel
SAR by interligand nuclear ove ...... ve against Bcl-x(L) and Mcl-1.
@en
P2093
P2860
P356
P1476
SAR by interligand nuclear ove ...... ve against Bcl-x(L) and Mcl-1.
@en
P2093
Jason F Cellitti
Maurizio Pellecchia
Michele F Rega
Ziming Zhang
P2860
P304
P356
10.1021/JM200826S
P407
P577
2011-08-04T00:00:00Z